2. Gene
  3. Fus - fused in sarcoma Gene

Fus - fused in sarcoma Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tls; Fus1; D430004D17Rik; D930039C12Rik

Gene ID: 233908 | Gene type: protein coding

About Fus

Summary

Enables mRNA 3'-UTR binding activity. Acts upstream of or within RNA splicing. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and lung. Used to study amyotrophic lateral sclerosis type 6. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 6; essential tremor 4; liposarcoma; and neurodegenerative disease. Orthologous to human FUS (FUS RNA binding protein). [provided by Alliance of Genome Resources, Apr 2022]

Fus Products(2)

mRNA Protein Name
NM_001347649.1 NP_001334578.1 RNA-binding protein FUS isoform 2
NM_139149.2 NP_631888.1 RNA-binding protein FUS isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
27378374 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
23681068 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within RNA splicing IMP
IMP: Inferred from mutant phenotype
27378374 MGI
acts upstream of or within gene expression IGI
IGI: Inferred from genetic interaction
27378374 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
27378374 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
34021139 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
12950080 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34021139 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12950080 MGI
is active in postsynaptic cytosol IDA
IDA: Inferred from direct assay
34021139 MGI
is active in presynaptic cytosol IDA
IDA: Inferred from direct assay
34021139 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

RNA-binding protein FUS

fusion, derived from t(12

16) malignant liposarcoma

hnRNP P2

pigpen protein

protein pigpen

translocated in liposarcoma

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-147410 Ulefnersen / Phase 3
Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-147410A Ulefnersen sodium 94.55% Unkown
HY-RS05149 FUS Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fus NCBI NCBI:2521
Canis familiaris Fus NCBI NCBI:100856381
Macaca fascicularis Fus NCBI NCBI:101925561