GPR161 - G protein-coupled receptor 161 Gene

Homo sapiens

Also known as RE2

Gene ID: 23432 | Gene type: protein coding

About GPR161

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,079,542-168,137,667 (from NCBI)

This gene has 11 transcripts (splice variants), 207 orthologues, 25 paralogues and is associated with 1 phenotype. Broad expression in endometrium (RPKM 8.0), esophagus (RPKM 3.6) and 20 other tissues.

Summary

The protein encoded by this gene is an orphan G protein-coupled receptor whose ligand is unknown. This gene is overexpressed in triple-negative breast Cancer, and disruption of this gene slows the proliferation of basal breast Cancer cells. Therefore, this gene is a potential drug target for triple-negative breast Cancer. [provided by RefSeq, Mar 2017]

GPR161 Products(15)

mRNA	Protein	Name
NM_001267609.1	NP_001254538.1	G-protein coupled receptor 161 isoform 1
NM_001267610.2	NP_001254539.1	G-protein coupled receptor 161 isoform 2
NM_001267611.1	NP_001254540.1	G-protein coupled receptor 161 isoform 3
NM_001267612.2	NP_001254541.1	G-protein coupled receptor 161 isoform 4
NM_001267613.1	NP_001254542.1	G-protein coupled receptor 161 isoform 5
NM_001267614.1	NP_001254543.1	G-protein coupled receptor 161 isoform 6
NM_001349632.1	NP_001336561.1	G-protein coupled receptor 161 isoform 2
NM_001349633.1	NP_001336562.1	G-protein coupled receptor 161 isoform 2
NM_001349634.1	NP_001336563.1	G-protein coupled receptor 161 isoform 2
NM_001349635.1	NP_001336564.1	G-protein coupled receptor 161 isoform 4
NM_001375883.1	NP_001362812.1	G-protein coupled receptor 161 isoform 2
NM_001375884.1	NP_001362813.1	G-protein coupled receptor 161 isoform 2
NM_001375885.1	NP_001362814.1	G-protein coupled receptor 161 isoform 2
NM_001381909.1	NP_001368838.1	G-protein coupled receptor 161 isoform 2
NM_153832.3	NP_722561.1	G-protein coupled receptor 161 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR161 Protein Structure

7tm_1

0
100
200
300
400
500
529 a.a.

Protein Preferred Names

Protein Names

G-protein coupled receptor 161

G-protein coupled receptor RE2

Related Diseases

Diseases

Alias

Medulloblastoma

MDB	Cpnet
Localized Primitive Neuroectodermal Tumor	Classic Medulloblastoma
Medulloblastoma Predisposition Syndrome	Medulloblastoma, Somatic
Brain Medulloblastoma	Cns Pnet
Infratentorial Primitive Neuroectodermal Tumor	Neuroectodermal Tumors, Primitive
Medulloblastomas	Desmoplastic Medulloblastoma
Medulloblastoma, With Extensive Nodularity	Medulloblastoma Of Unspecified Site
Medullomyoblastoma Of Unspecified Site

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Pituitary Adenoma 2, Growth Hormone-Secreting

PITA2	Acromegaly Due To Pituitary Adenoma 2
Acromegaly, X-Linked	Growth Hormone Secreting Pituitary Adenoma 2
Pituitary Adenoma, Growth Hormone-Secreting, 2	Pituitary Adenoma 2, Gh-Secreting
Gh-Secreting Pituitary Adenoma 2	X-Linked Acromegaly
Adenoma, Pituitary, Growth Hormone-Secreting, Type 2

Alstrom Syndrome

ALMS	Alström Syndrome
Alss	Alstrom-Hallgren Syndrome
Alstroem Syndrome

Bardet-Biedl Syndrome

Bbs	Biedl-Bardet Syndrome

Joubert Syndrome 32

JBTS32

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Basal Cell Nevus Syndrome

Nevoid Basal Cell Carcinoma Syndrome	Gorlin Syndrome
Nbccs	BCNS
Gorlin-Goltz Syndrome	Multiple Basal Cell Nevi, Odontogenic Keratocysts, And Skeletal Anomalies
Cerebral Gigantism Jaw Cysts	Cramer Niederdellmann Syndrome
Gorlin Syndrome Or Gorlin-Goltz Syndrome	Naevoid Basal Cell Carcinoma Syndrome

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ellis-Van Creveld Syndrome

Chondroectodermal Dysplasia	Mesoectodermal Dysplasia
EVC	Ellis Van Creveld Syndrome
Mesodermic Dysplasia	Ellis-Van Creveld Dysplasia

Meckel Syndrome, Type 1

Meckel-Gruber Syndrome	Meckel Syndrome
Dysencephalia Splanchnocystica	Meckel Syndrome 1
MKS1	Mks
Gruber Syndrome	Meckel-Gruber Syndrome, Type 1
Mes	Dysencephalia Splachnocystica
Meckel Gruber Syndrome	Meckel Syndrome Type 1

Nephronophthisis

Medullary Cystic Disease	Medullary Cystic Kidney
Nph	Nphp
Kidney Disease, Cystic, Medullary

Fundus Dystrophy

Retinal Dystrophy	Retinal Dystrophies
Dystrophy, Retinal

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05677	GPR161 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GPR161	VGNC	VGNC:72991
Bos taurus	GPR161	VGNC	VGNC:29566
Canis familiaris	GPR161	VGNC	VGNC:41412
Rattus norvegicus	GPR161	RGD	RGD:1563245
Mus musculus	GPR161	MGD	MGI:2685054
Felis catus	GPR161	VGNC	VGNC:62684

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