2. Gene
  3. SLC30A2 - solute carrier family 30 member 2 Gene

SLC30A2 - solute carrier family 30 member 2 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as TNZD; ZNT2; ZnT-2; PP12488

Gene ID: 7780 | Gene type: protein coding

About SLC30A2

Cytogenetic location: 1p36.11 Genomic coordinates (GRCh38): 1:26,037,252-26,046,118 (from NCBI)

This gene has 3 transcripts (splice variants), 265 orthologues, 8 paralogues and is associated with 1 phenotype. Biased expression in thyroid (RPKM 19.5), kidney (RPKM 11.8) and 4 other tissues.

Summary

The protein encoded by this gene is a zinc transporter that acts as a homodimer. The encoded protein plays a role in secreting zinc into breast milk. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]

SLC30A2 Products(2)

mRNA Protein Name
NM_001004434.3 NP_001004434.1 zinc transporter 2 isoform 1
NM_032513.5 NP_115902.1 zinc transporter 2 isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IDA
IDA: Inferred from direct assay
22733820 GOA
enables identical protein binding IPI
IPI: Inferred from physical interaction
25657003 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables zinc ion transmembrane transporter activity IDA
IDA: Inferred from direct assay
17349999 GOA
enables zinc:proton antiporter activity IDA
IDA: Inferred from direct assay
30893306 GOA
Biological Process GO Annotation Evidence Reference Source
involved in zinc export across plasma membrane IDA
IDA: Inferred from direct assay
19496757 GOA
involved in zinc ion import into lysosome IDA
IDA: Inferred from direct assay
17349999 GOA
involved in zinc ion import into lysosome IMP
IMP: Inferred from mutant phenotype
25808614 GOA
involved in zinc ion import into organelle IDA
IDA: Inferred from direct assay
21289295 GOA
involved in zinc ion import into organelle IMP
IMP: Inferred from mutant phenotype
22733820 GOA
involved in zinc ion import into secretory vesicle IDA
IDA: Inferred from direct assay
19496757 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17349999 GOA
located in endosome membrane IDA
IDA: Inferred from direct assay
19496757 GOA
located in late endosome IDA
IDA: Inferred from direct assay
17349999 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
25808614 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
21289295 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19496757 GOA
located in secretory vesicle IDA
IDA: Inferred from direct assay
19496757 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC30A2 Protein Structure

Cation_efflux

Cation_efflux: Cation efflux family (90 - 311)

  • 0
  • 100
  • 200
  • 300
  • 323 a.a.
Protein Preferred Names Protein Names

zinc transporter 2

solute carrier family 30 (zinc transporter), member 2

SLC30A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q08AM2
Y2H Array
25416956
Intra
SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q08AM2
Y2H Prey Pooling
25416956
Intra
SLC30A2 Q9BRI3 CCL4L1 Homo sapiens Q8NHW4
Y2H Prey Pooling
25416956
Intra
SLC30A2 Q9BRI3 CCL4L1 Homo sapiens Q8NHW4
Y2H Array
25416956
Intra
SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
IF
25657003
Intra
SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
Anti Tag CoIP
26728129
Intra
SLC30A2 Q9BRI3 SLC30A3 Homo sapiens Q99726
BiFC
25657003
Intra
SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q9BZ11-2
Validated Y2H
25416956
Intra
SLC30A2 Q9BRI3 ADAM33 Homo sapiens Q9BZ11-2
Y2H Array
25416956
Intra
SLC30A2 Q9BRI3 SLC38A7 Homo sapiens Q9NVC3
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 IL10RA Homo sapiens Q13651
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 IL10RA Homo sapiens Q13651
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 LYVE1 Homo sapiens Q9Y5Y7
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC30A1 Homo sapiens Q9Y6M5
BiFC
25657003
Intra
SLC30A2 Q9BRI3 ATP13A1 Homo sapiens Q9HD20-3
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 MS4A13 Homo sapiens Q5J8X5
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC39A2 Homo sapiens Q9NP94
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SLC7A8 Homo sapiens Q9UHI5
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TM4SF18 Homo sapiens Q96CE8
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TM4SF18 Homo sapiens Q96CE8
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SLC30A10 Homo sapiens Q6XR72
Anti Tag CoIP
26728129
Intra
SLC30A2 Q9BRI3 SLC30A4 Homo sapiens O14863
BiFC
25657003
Intra
SLC30A2 Q9BRI3 GOLT1A Homo sapiens Q6ZVE7
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 GOLT1A Homo sapiens Q6ZVE7
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC18A1 Homo sapiens P54219-3
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC18A1 Homo sapiens P54219-3
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 PCNX2 Homo sapiens A6NKB5-5
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 PCNX2 Homo sapiens A6NKB5-5
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 EVI2B Homo sapiens P34910-2
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 EVI2B Homo sapiens P34910-2
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TSPAN31 Homo sapiens Q12999
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TSPAN31 Homo sapiens Q12999
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SELL Homo sapiens P14151-2
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SELL Homo sapiens P14151-2
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 TAS2R5 Homo sapiens Q9NYW4
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 PLPPR1 Homo sapiens Q8TBJ4
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 PLPPR1 Homo sapiens Q8TBJ4
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 GPR42 Homo sapiens O15529
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GPR42 Homo sapiens O15529
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC10A6 Homo sapiens Q3KNW5
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 SLC10A6 Homo sapiens Q3KNW5
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 FAM174A Homo sapiens Q8TBP5
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 FAM174A Homo sapiens Q8TBP5
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Y2H Prey Pooling
25416956
Intra
SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Validated Y2H
25416956
Intra
SLC30A2 Q9BRI3 TNFRSF12A Homo sapiens Q9NP84
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 TMEM60 Homo sapiens Q9H2L4
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Validated Y2H
25416956
Intra
SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Array
25416956
Intra
SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Array
31515488
Intra
SLC30A2 Q9BRI3 CCL4 Homo sapiens P13236
Y2H Prey Pooling
25416956
Intra
SLC30A2 Q9BRI3 KCNN4 Homo sapiens O15554
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 KCNN4 Homo sapiens O15554
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 EMP3 Homo sapiens P54852
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Array
31515488
Intra
SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Prey Pooling
25416956
Intra
SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 PVR Homo sapiens P15151
Validated Y2H
25416956
Intra
SLC30A2 Q9BRI3 SLC7A1 Homo sapiens P30825
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 SLC7A1 Homo sapiens P30825
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 CD40 Homo sapiens P25942
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 CD40 Homo sapiens P25942
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Validated Y2H
25910212
Intra
SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Y2H Bait-Prey Pool
25910212
Intra
SLC30A2 Q9BRI3 CREB3 Homo sapiens O43889-2
Y2H Array
25910212
Intra
SLC30A2 Q9BRI3 GPR161 Homo sapiens Q8N6U8
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GPR161 Homo sapiens Q8N6U8
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 FXYD6 Homo sapiens Q9H0Q3
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 NDUFAF1 Homo sapiens Q9Y375
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 F11R Homo sapiens Q9Y624
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Validated Y2H
25910212
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
25910212
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
25416956
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Bait-Prey Pool
25910212
Intra
SLC30A2 Q9BRI3 KASH5 Homo sapiens Q8N6L0
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 GJA5 Homo sapiens P36382
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 GJA5 Homo sapiens P36382
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 YIPF2 Homo sapiens Q9BWQ6
Validated Y2H
32296183
Intra
SLC30A2 Q9BRI3 CD79A Homo sapiens P11912
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 CD79A Homo sapiens P11912
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 EBAG9 Homo sapiens O00559
Y2H Array
32296183
Intra
SLC30A2 Q9BRI3 EBAG9 Homo sapiens O00559
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 FDPS Homo sapiens P14324
Y2H Prey Pooling
32296183
Intra
SLC30A2 Q9BRI3 FDPS Homo sapiens P14324
Y2H Array
32296183
Cross
SLC30A2 Q9BRI3 Tfrc Rattus norvegicus Q99376
Anti Tag CoIP
26728129
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Zinc Deficiency, Transient Neonatal

TNZD

Zinc Deficiency, Neonatal, Due To Low Breast Milk Zinc

Neonatal Zinc Deficiency Due To Low Breast Milk Zinc
Acrodermatitis Enteropathica, Zinc-Deficiency Type

Acrodermatitis Enteropathica

AEZ

Enteropathica

Brandt Syndrome

Ae

Acrodermatitis Enteropathica Zinc Deficiency Type

Danbolt-Cross Syndrome

Acrodermatitis Enteropathica, Zinc Deficiency Type

Inherited Zinc Deficiency

Acrodermatitis Enteropathica, Zinc Deficiency

Danbolt-Closs Syndrome

Primary Zinc Malabsorption Syndrome
Hypermanganesemia With Dystonia 2

HMNDYT2

Dystonia-Parkinsonism-Hypermanganesemia Syndrome

Hypermanganesemia With Dystonia, Type 2
Hypermanganesemia With Dystonia

Familial Manganese-Induced Neurotoxicity

Hmndyt
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

Scd-Eds

EDSSPD3

Ehlers-Danlos Syndrome Spondylodysplastic Type 3

Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

Slc39a13-Related Speds

Slc39a13-Related Spondylodysplastic Eds

Spondylocheirodysplastic Ehlers-Danlos Syndrome

Speds-Slc39a13

Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Hypermanganesemia With Dystonia 1

Hypermanganesemia With Dystonia, Polycythemia, And Cirrhosis

HMNDYT1

Hmdpc

Hypermanganesemia With Dystonia Polycythemia And Cirrhosis

Dystonia/Parkinsonism, Hypermanganesemia, Polycythemia, Chronic Liver Disease

Cirrhosis-Dystonia-Polycythemia-Hypermanganesemia Syndrome
Acrodermatitis
Metal Metabolism Disorder

Metal Metabolism, Inborn Errors

Inborn Metal Metabolism Disorder
Menkes Disease

Copper Transport Disease

Menkes Syndrome

MNK

Kinky Hair Disease

Steely Hair Disease

Menkes Kinky-Hair Syndrome

Mk

Steely Hair Syndrome

Menkea Syndrome

Md

Menkes Kinky Hair Syndrome

Hypocupremia, Congenital

Kinky Hair Syndrome

X-Linked Copper Deficiency

Menkes Kinky Hair Disease
Hemochromatosis, Type 1

Hemochromatosis

Hemochromatosis Type 1

Hereditary Hemochromatosis

Hh

HFE1

Hfe Hemochromatosis, Modifier Of

Symptomatic Form Of Classic Hemochromatosis

Symptomatic Form Of Hemochromatosis Type 1

Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

Haemochromatosis

Iron Storage Disorder

Bronze Diabetes

Hereditary Haemochromatosis

Hlah

Hfe

Hemochromatosis, Hereditary

Diabetes Bronze

Classic Hemochromatosis

Hfe-Associated Hereditary Hemochromatosis

Hemochromatosis Classic

Bronzed Cirrhosis

Familial Hemochromatosis

Genetic Hemochromatosis

Hc

Pigmentary Cirrhosis

Primary Hemochromatosis

Troisier-Hanot-Chauffard Syndrome

Von Recklenhausen-Applebaum Disease

Hemochromatosis 1

Primary Hereditary Hemochromatosis

Bronze Cirrhosis
Ehlers-Danlos Syndrome

Eds

Cutis Hyperelastica

Elastic Skin

Ehlers-Danlos Syndromes

Ed Syndrome

Ehlers Danlos Syndrome

Ehlers Danlos Disease

Eds - [Ehlers-Danlos Syndrome]
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13180 SLC30A2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC30A2 VGNC VGNC:77452
Rattus norvegicus SLC30A2 RGD RGD:3707
Canis familiaris SLC30A2 VGNC VGNC:46347
Bos taurus SLC30A2 VGNC VGNC:34807
Mus musculus SLC30A2 MGD MGI:106637
Felis catus SLC30A2 VGNC VGNC:107622
Others SLC30A2 NCBI