OTP - orthopedia homeobox Gene

Homo sapiens

Gene ID: 23440 | Gene type: protein coding

About OTP

Cytogenetic location: 5q14.1 Genomic coordinates (GRCh38): 5:77,628,712-77,638,713 (from NCBI)

This gene has 2 transcripts (splice variants), 247 orthologues and 50 paralogues. Low expression observed in reference dataset.

Summary

This gene encodes a member of the homeodomain (HD) family. HD family proteins are helix-turn-helix transcription factors that play key roles in the specification of cell fates. This protein may function during brain development. [provided by RefSeq, Jul 2008]

OTP Products(1)

mRNA	Protein	Name
NM_032109.3	NP_115485.1	homeobox protein orthopedia

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	29107289	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	29107289	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	29107289	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OTP Protein Structure

Homeobox

OAR

0
100
200
300
325 a.a.

Protein Preferred Names

Protein Names

homeobox protein orthopedia

orthopedia homolog

OTP Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OTP	Q5XKR4	CPNE7	Homo sapiens	Q9UBL6-2	Validated Y2H	32296183
Intra	OTP	Q5XKR4	SLC12A7	Homo sapiens	Q9Y666-2	Validated Y2H	32296183
Intra	OTP	Q5XKR4	EOMES	Homo sapiens	O95936-4	Y2H Array	32296183
Intra	OTP	Q5XKR4	EOMES	Homo sapiens	O95936-4	Y2H Prey Pooling	32296183
Intra	OTP	Q5XKR4	BEX1	Homo sapiens	Q9HBH7	Validated Y2H	32296183
Intra	OTP	Q5XKR4	TPGS2	Homo sapiens	Q68CL5	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Axenfeld-Rieger Syndrome, Type 3

Axenfeld-Rieger Syndrome Type 3	RIEG3
Anterior Chamber Cleavage Syndrome	Anterior Segment Mesenchymal Dysgenesis
Axenfeld-Rieger Anomaly With Cardiac Defects And/Or Sensorineural Hearing Loss	Axenfeld-Rieger Anomaly With Or Without Cardiac Defects And/Or Sensorineural Hearing Loss
Rieger Syndrome Type 3	Axenfeld-Rieger Anomaly
Rieger Syndrome, Type 3	Axenfeld-Rieger Syndrome 3
Axenfeld Anomaly	Rieger Anomaly
Rieger Syndrome	Rieger Eye Malformation Sequence

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Axenfeld-Rieger Syndrome

Axenfeld Syndrome	Rieger Syndrome
Rieger Anomaly	Axenfeld Anomaly
Anomaly, Rieger'S	Hagedoom Syndrome
Rgs - Rieger Syndrome	Rieger'S Anomaly
Goniodysgenesis Hypodontia	Iridogoniodysgenesis With Somatic Anomalies
Ars	Axenfeld And Rieger Anomaly
Axra	Axrs
Rieger Eye Malformation Sequence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09868	OTP Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	OTP	VGNC	VGNC:44182
Mus musculus	OTP	MGD	MGI:99835
Macaca mulatta	OTP	VGNC	VGNC:84457
Rattus norvegicus	OTP	RGD	RGD:727945
Felis catus	OTP	VGNC	VGNC:102277
Bos taurus	OTP	VGNC	VGNC:55130

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