BEX1 - brain expressed X-linked 1 Gene

Homo sapiens

Also known as BEX2; HBEX2; HGR74-h

Gene ID: 55859 | Gene type: protein coding

About BEX1

Cytogenetic location: Xq22.1 Genomic coordinates (GRCh38): X:103,062,651-103,064,171 (from NCBI)

This gene has 1 transcript (splice variant), 145 orthologues and 3 paralogues. Biased expression in brain (RPKM 178.4), testis (RPKM 38.4) and 3 other tissues.

Summary

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity. Involved in positive regulation of DNA-binding transcription factor activity and positive regulation of transcription by RNA polymerase II. Part of transcription regulator complex. [provided by Alliance of Genome Resources, Apr 2022]

BEX1 Products(1)

mRNA	Protein	Name
NM_018476.4	NP_060946.3	protein BEX1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II-specific DNA-binding transcription factor binding	IPI IPI: Inferred from physical interaction	16314316	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	16314316	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16314316	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of transcription regulator complex	IDA IDA: Inferred from direct assay	16314316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BEX1 Protein Structure

BEX

0
100
125 a.a.

Protein Preferred Names

Protein Names

protein BEX1

brain-expressed X-linked protein 1

BEX1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BEX1	Q9HBH7	KRT34	Homo sapiens	O76011	Y2H Array	32296183
Intra	BEX1	Q9HBH7	KRT34	Homo sapiens	O76011	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	KLHL20	Homo sapiens	Q9BS75	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	KLHL20	Homo sapiens	Q9BS75	Y2H Array	32296183
Intra	BEX1	Q9HBH7	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	BEX1	Q9HBH7	OTP	Homo sapiens	Q5XKR4	Y2H Array	32296183
Intra	BEX1	Q9HBH7	OTP	Homo sapiens	Q5XKR4	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	BEX1	Q9HBH7	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	BEX1	Q9HBH7	MAGEA2	Homo sapiens	P43356	Y2H Array	32296183
Intra	BEX1	Q9HBH7	MAGEA2	Homo sapiens	P43356	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	BEX1	Q9HBH7	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	25416956
Intra	BEX1	Q9HBH7	TEX11	Homo sapiens	Q8IYF3	Validated Y2H	25416956
Intra	BEX1	Q9HBH7	CNOT2	Homo sapiens	Q9NZN8	Validated Y2H	32296183
Intra	BEX1	Q9HBH7	PICK1	Homo sapiens	Q9NRD5	Y2H Array	32296183
Intra	BEX1	Q9HBH7	PICK1	Homo sapiens	Q9NRD5	Y2H Prey Pooling	32296183
Intra	BEX1	Q9HBH7	PICK1	Homo sapiens	Q9NRD5	Validated Y2H	32296183
Intra	BEX1	Q9HBH7	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	BEX1	Q9HBH7	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01480	BEX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	BEX1	RGD	RGD:1564466

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