SEC61G - SEC61 translocon subunit gamma Gene

Homo sapiens

Also known as SSS1

Gene ID: 23480 | Gene type: protein coding

About SEC61G

Cytogenetic location: 7p11.2 Genomic coordinates (GRCh38): 7:54,752,253-54,759,211 (from NCBI)

This gene has 7 transcripts (splice variants) and 250 orthologues. Ubiquitous expression in colon (RPKM 71.5), prostate (RPKM 56.4) and 25 other tissues.

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the gamma-subunit protein. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

SEC61G Products(2)

mRNA	Protein	Name
NM_001012456.2	NP_001012474.1	protein transport protein Sec61 subunit gamma
NM_014302.4	NP_055117.1	protein transport protein Sec61 subunit gamma

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA
enables ribosome binding	IDA IDA: Inferred from direct assay	32820719	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IDA IDA: Inferred from direct assay	22375059	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC61G Protein Structure

SecE

0
68 a.a.

Protein Preferred Names

Protein Names

protein transport protein Sec61 subunit gamma

SEC61 translocon gamma subunit

SEC61G Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SEC61G	P60059	SFTPC	Homo sapiens	P11686	Y2H Array	25416956
Intra	SEC61G	P60059	SFTPC	Homo sapiens	P11686	Y2H Prey Pooling	25416956
Intra	SEC61G	P60059	LRRC25	Homo sapiens	Q8N386	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	LRRC25	Homo sapiens	Q8N386	Validated Y2H	32296183
Intra	SEC61G	P60059	LRRC25	Homo sapiens	Q8N386	Y2H Array	32296183
Intra	SEC61G	P60059	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	LCN2	Homo sapiens	P80188	Validated Y2H	32296183
Intra	SEC61G	P60059	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	SEC61G	P60059	AQP6	Homo sapiens	Q13520	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	AQP6	Homo sapiens	Q13520	Validated Y2H	32296183
Intra	SEC61G	P60059	AQP6	Homo sapiens	Q13520	Y2H Array	32296183
Intra	SEC61G	P60059	FAM209A	Homo sapiens	Q5JX71	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	FAM209A	Homo sapiens	Q5JX71	Validated Y2H	32296183
Intra	SEC61G	P60059	FAM209A	Homo sapiens	Q5JX71	Y2H Array	32296183
Intra	SEC61G	P60059	PEX12	Homo sapiens	O00623	Y2H Array	32296183
Intra	SEC61G	P60059	PEX12	Homo sapiens	O00623	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	CREB3L1	Homo sapiens	Q96BA8	Y2H Prey Pooling	32296183
Intra	SEC61G	P60059	CREB3L1	Homo sapiens	Q96BA8	Validated Y2H	32296183
Intra	SEC61G	P60059	CREB3L1	Homo sapiens	Q96BA8	Y2H Array	32296183
Intra	SEC61G	P60059	TMEM51	Homo sapiens	Q9NW97	Validated Y2H	32296183
Intra	SEC61G	P60059	TMEM51	Homo sapiens	Q9NW97	Y2H Array	32296183
Intra	SEC61G	P60059	TMEM51	Homo sapiens	Q9NW97	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Childhood Ependymoma

Autosomal Dominant Severe Congenital Neutropenia

Severe Congenital Neutropenia Autosomal Dominant

Neutropenia, Congenital, Severe, Autosomal Dominant

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12623	SEC61G Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SEC61G	VGNC	VGNC:49154
Mus musculus	SEC61G	MGD	MGI:1202066
Rattus norvegicus	SEC61G	RGD	RGD:1596170
Macaca mulatta	SEC61G	VGNC	VGNC:108436
Canis familiaris	SEC61G	VGNC	VGNC:49617

Name
Email *

	Sorry, but the email address you supplied was invalid.