LRRC8B - leucine rich repeat containing 8 VRAC subunit B Gene

Homo sapiens

Also known as TALRRP; TA-LRRP

Gene ID: 23507 | Gene type: protein coding

About LRRC8B

Cytogenetic location: 1p22.2 Genomic coordinates (GRCh38): 1:89,524,338-89,597,861 (from NCBI)

This gene has 5 transcripts (splice variants), 133 orthologues and 31 paralogues. Broad expression in brain (RPKM 8.6), adrenal (RPKM 5.3) and 25 other tissues.

Summary

Contributes to volume-sensitive anion channel activity. Involved in anion transmembrane transport. Located in cytoplasm and plasma membrane. Is integral component of plasma membrane. Part of ion channel complex. [provided by Alliance of Genome Resources, Apr 2022]

LRRC8B Products(4)

mRNA	Protein	Name
NM_001134476.2	NP_001127948.1	volume-regulated anion channel subunit LRRC8B
NM_001369817.2	NP_001356746.1	volume-regulated anion channel subunit LRRC8B
NM_001369819.2	NP_001356748.1	volume-regulated anion channel subunit LRRC8B
NM_015350.4	NP_056165.1	volume-regulated anion channel subunit LRRC8B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24790029	GOA
contributes to volume-sensitive anion channel activity	IMP IMP: Inferred from mutant phenotype	28193731	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in monoatomic anion transmembrane transport	IMP IMP: Inferred from mutant phenotype	24790029	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	24790029	GOA
part of monoatomic ion channel complex	IMP IMP: Inferred from mutant phenotype	28193731	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	24790029	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	28193731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRRC8B Protein Structure

Pannexin_like

LRR_8

LRR_1

0
200
400
600
803 a.a.

Protein Preferred Names

Protein Names

volume-regulated anion channel subunit LRRC8B

T-cell activation leucine repeat-rich protein

Related Diseases

Diseases

Alias

Spinocerebellar Ataxia 44

SCA44

Cornelia De Lange Syndrome 1

De Lange Syndrome	CDLS1
Cdl	Cdls
Typus Degenerativus Amstelodamensis	Brachmann-De Lange Syndrome
Bdls	Amstelodamensis Typus Degenerativus
Cornelia De Lange Syndrome, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07828	LRRC8B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LRRC8B	RGD	RGD:1563429
Canis familiaris	LRRC8B	VGNC	VGNC:42815
Mus musculus	LRRC8B	MGD	MGI:2141353
Macaca mulatta	LRRC8B	VGNC	VGNC:81439
Bos taurus	LRRC8B	VGNC	VGNC:31030

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