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  3. MORC3 - MORC family CW-type zinc finger 3 Gene

MORC3 - MORC family CW-type zinc finger 3 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NXP2; ZCW5; ZCWCC3

Gene ID: 23515 | Gene type: protein coding

About MORC3

Cytogenetic location: 21q22.12 Genomic coordinates (GRCh38): 21:36,320,197-36,376,632 (from NCBI)

This gene has 12 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 15.2), ovary (RPKM 12.6) and 25 other tissues.

Summary

This gene encodes a protein that localizes to the nuclear matrix and forms nuclear bodies via an ATP-dependent mechanism. The protein is predicted to have coiled-coil and zinc finger domains and has RNA binding activity. Alternative splicing produces multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Feb 2016]

MORC3 Products(3)

mRNA Protein Name
NM_001320445.2 NP_001307374.1 MORC family CW-type zinc finger protein 3 isoform 2
NM_001320446.2 NP_001307375.1 MORC family CW-type zinc finger protein 3 isoform 2
NM_015358.3 NP_056173.1 MORC family CW-type zinc finger protein 3 isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables DNA binding IDA
IDA: Inferred from direct assay
34759314 GOA
enables methylated histone binding IDA
IDA: Inferred from direct assay
26933034 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
26496610 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
27440897 GOA
Biological Process GO Annotation Evidence Reference Source
involved in antiviral innate immune response IDA
IDA: Inferred from direct assay
27440897 GOA
acts upstream of or within maintenance of protein location in nucleus IDA
IDA: Inferred from direct assay
17332504 GOA
acts upstream of or within maintenance of protein location in nucleus IMP
IMP: Inferred from mutant phenotype
17332504 GOA
acts upstream of or within negative regulation of fibroblast proliferation IDA
IDA: Inferred from direct assay
17332504 GOA
involved in negative regulation of interferon-beta production IDA
IDA: Inferred from direct assay
34759314 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
34759314 GOA
acts upstream of or within peptidyl-serine phosphorylation IDA
IDA: Inferred from direct assay
17332504 GOA
acts upstream of or within positive regulation of cellular senescence IDA
IDA: Inferred from direct assay
17332504 GOA
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
17332504 GOA
acts upstream of or within protein stabilization IDA
IDA: Inferred from direct assay
17332504 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in PML body IDA
IDA: Inferred from direct assay
27440897 GOA
located in PML body IDA
IDA: Inferred from direct assay
17332504 GOA
located in chromatin IDA
IDA: Inferred from direct assay
34759314 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MORC3 Protein Structure

HATPase_c_3

HATPase_c_3: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (30 - 129)

zf-CW

zf-CW: CW-type Zinc Finger (408 - 452)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 939 a.a.
Protein Preferred Names Protein Names

MORC family CW-type zinc finger protein 3

nuclear matrix protein 2

MORC3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
MORC3 Q14149 DYNLL1 Homo sapiens P63167
Anti Tag CoIP
26496610
Intra
MORC3 Q14149 DYNLL1 Homo sapiens P63167
Y2H Fragment Pooling
35914814
Intra
MORC3 Q14149 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
Intra
MORC3 Q14149 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
Intra
MORC3 Q14149 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant MORC3 Proteins

Cat. No. Product Name Accession Purity
HY-P71545 MORC3 Protein, Human (His-SUMO) Q14149 (1M-290Y) ≥95%

Related Diseases

Diseases Alias
Adult Dermatomyositis

Adult Onset Dermatomyositis

Adult Type Dermatomyositis
Antisynthetase Syndrome

As Syndrome

Anti-Jo1 Syndrome
Orbital Plasma Cell Granuloma

Orbital Myositis

Orbital Pseudotumor

Pseudotumor Of Orbit

Plasma Cell Granuloma, Orbital
Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified
Renal Pelvis Squamous Cell Carcinoma

Epidermoid Carcinoma Of The Kidney Pelvis

Squamous Cell Carcinoma Of Renal Pelvis
Childhood Type Dermatomyositis

Juvenile Dermatomyositis

Juvenile Dm

Childhood Dermatomyositis

Amyopathic Dermatomyositis

Adm

Dermatomyositis Sine Myositis

Dermatomyositis, Childhood Type
Chronic Orbital Inflammation

Chronic Inflammation Of Orbit
Nodular Prostate
Muscle Tissue Disease
Exanthem

Exanthema

Rash

Rashes
Muscular Disease
Myopathy

Muscular Diseases

Myopathies
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08591 MORC3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta MORC3 VGNC VGNC:74809
Rattus norvegicus MORC3 RGD RGD:1307924
Bos taurus MORC3 VGNC VGNC:31556
Mus musculus MORC3 MGD MGI:2136841
Canis familiaris MORC3 VGNC VGNC:43318
Felis catus MORC3 VGNC VGNC:63558
Others MORC3 NCBI