2. Gene
  3. ARHGAP45 - Rho GTPase activating protein 45 Gene

ARHGAP45 - Rho GTPase activating protein 45 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as HA-1; HMHA1; HLA-HA1

Gene ID: 23526 | Gene type: protein coding

About ARHGAP45

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:1,065,959-1,086,628 (from NCBI)

This gene has 16 transcripts (splice variants), 214 orthologues and 2 paralogues. Broad expression in spleen (RPKM 23.6), bone marrow (RPKM 17.0) and 22 other tissues.

Summary

Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

ARHGAP45 Products(5)

mRNA Protein Name
NM_001258328.4 NP_001245257.1 rho GTPase-activating protein 45 isoform 2 precursor
NM_001282334.2 NP_001269263.1 rho GTPase-activating protein 45 isoform 3
NM_001282335.3 NP_001269264.1 rho GTPase-activating protein 45 isoform 4
NM_001321232.2 NP_001308161.1 rho GTPase-activating protein 45 isoform 5
NM_012292.5 NP_036424.2 rho GTPase-activating protein 45 isoform 1 precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
24086303 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP45 Protein Structure

RhoGAP

RhoGAP: RhoGAP domain (775 - 945)

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  • 1136 a.a.
Protein Preferred Names Protein Names

rho GTPase-activating protein 45

histocompatibility (minor) HA-1

ARHGAP45 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Y2H Array
32296183
Intra
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 PPP1R13B Homo sapiens Q96KQ4
Validated Y2H
32296183
Intra
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Validated Y2H
32296183
Intra
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Y2H Array
32296183
Intra
ARHGAP45 Q92619 GMIP Homo sapiens Q9P107
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 TP53BP2 Homo sapiens Q05BL1
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 TP53BP2 Homo sapiens Q05BL1
Y2H Array
32296183
Intra
ARHGAP45 Q92619 BICD2 Homo sapiens Q8TD16-2
Y2H Array
32296183
Intra
ARHGAP45 Q92619 BICD2 Homo sapiens Q8TD16-2
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 PIBF1 Homo sapiens Q4G0R1
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 PIBF1 Homo sapiens Q4G0R1
Y2H Array
32296183
Intra
ARHGAP45 Q92619 RAC1 Homo sapiens P63000
FACS
24086303
Intra
ARHGAP45 Q92619 RAC1 Homo sapiens P63000
Confocal
24086303
Intra
ARHGAP45 Q92619 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ARHGAP45 Q92619 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 HSF2BP Homo sapiens O75031
Y2H Array
32296183
Intra
ARHGAP45 Q92619 RINT1 Homo sapiens Q6NUQ1
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 RINT1 Homo sapiens Q6NUQ1
Y2H Array
32296183
Intra
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Validated Y2H
32296183
Intra
ARHGAP45 Q92619 ZUP1 Homo sapiens Q96AP4
Y2H Array
32296183
Intra
ARHGAP45 Q92619 PDE4DIP Homo sapiens Q5VU43-2
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 PDE4DIP Homo sapiens Q5VU43-2
Y2H Array
32296183
Intra
ARHGAP45 Q92619 TRIM50 Homo sapiens Q86XT4
Y2H Prey Pooling
32296183
Intra
ARHGAP45 Q92619 TRIM50 Homo sapiens Q86XT4
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Graft-Versus-Host Disease

Graft-Versus-Host Disease, Susceptibility To

Graft Versus Host Disease

GVHDS

Graft-Versus-Host Disease, Protection Against

Gvh

Graft-Vs-Host Disease

Gvhd - [Graft-Versus-Host Disease]

Graft-Versus-Host Reaction Or Disease

Gvh - [Graft-Versus-Host] Disease

Gvh - [Graft-Versus-Host] Reaction
Acute Graft Versus Host Disease

Acute Graft-Versus-Host Disease

Acute Gvhd

Acute Gvh Disease

Acute Gvhd - [Graft-Versus-Host Disease]
Leukemia

Leukemias

Leukaemia, Unspecified, Without Mention Of Remission

Aleukemic Leukaemia

Chronic Leukaemia

Subacute Leukaemia

Leukaemia Disorder

Leukaemia Nos
Hematologic Cancer

Hematologic Neoplasm

Hematologic Neoplasms

Hematologic Malignancies

Blood Cancer

Hematologic Malignancy

Hematological Tumors

Hematopoietic And Lymphoid System Tumor

Hematopoietic Cancer

Hematopoietic Neoplasm

Hematopoietic Tumors

Malignant Hematopoietic Neoplasm

Liquid Tumor

Hematopoietic Neoplasms
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00938 ARHGAP45 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ARHGAP45 VGNC VGNC:59894
Macaca mulatta ARHGAP45 VGNC VGNC:69847
Canis familiaris ARHGAP45 VGNC VGNC:38066
Rattus norvegicus ARHGAP45 RGD RGD:1308662
Bos taurus ARHGAP45 VGNC VGNC:59319
Mus musculus ARHGAP45 MGD MGI:1917969