SEC14L2 - SEC14 like lipid binding 2 Gene

Homo sapiens

Also known as SPF; TAP; TAP1; C22orf6

Gene ID: 23541 | Gene type: protein coding

About SEC14L2

Cytogenetic location: 22q12.2 Genomic coordinates (GRCh38): 22:30,397,018-30,425,303 (from NCBI)

This gene has 17 transcripts (splice variants), 201 orthologues and 6 paralogues. Biased expression in liver (RPKM 34.2), prostate (RPKM 20.5) and 7 other tissues.

Summary

This gene encodes a cytosolic protein which belongs to a family of lipid-binding proteins including Sec14p, alpha-tocopherol transfer protein, and cellular retinol-binding protein. The encoded protein stimulates squalene monooxygenase which is a downstream Enzyme in the Cholesterol biosynthetic pathway. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]

SEC14L2 Products(4)

mRNA	Protein	Name
NM_001204204.3	NP_001191133.1	SEC14-like protein 2 isoform 3
NM_001291932.2	NP_001278861.1	SEC14-like protein 2 isoform 4
NM_012429.5	NP_036561.1	SEC14-like protein 2 isoform 1
NM_033382.3	NP_203740.1	SEC14-like protein 2 isoform 2

SEC14L2 Protein Structure

CRAL_TRIO_N

CRAL_TRIO

0
100
200
300
403 a.a.

Protein Preferred Names

Protein Names

SEC14-like protein 2

alpha-tocopherol-associated protein

Related Diseases

Diseases

Alias

Plica Syndrome

Synovitis

Ataxia With Vitamin E Deficiency

Ataxia With Isolated Vitamin E Deficiency	AVED
Familial Isolated Vitamin E Deficiency	Friedreich-Like Ataxia
Familial Isolated Deficiency Of Vitamin E	Isolated Vitamin E Deficiency
Ataxia, Friedreich-Like, With Selective Vitamin E Deficiency	Vitamin E Deficiency, Familial Isolated
Ved	Friedreich-Like Ataxia With Selective Vitamin E Deficiency
Five	Friedreich Ataxia Phenotype With Selective Vitamin E Deficiency
Vitamin E Familial Isolated, Deficiency Of	Ataxia Friedreich-Like With Selective Vitamin E Deficiency

Ornithine Transcarbamylase Deficiency, Hyperammonemia Due To

Ornithine Carbamoyltransferase Deficiency	Ornithine Transcarbamylase Deficiency
Otc Deficiency	Ornithine Carbamoyltransferase Deficiency Disease
OTCD	Deficiency Of Citrulline Phosphorylase
Oct Deficiency	Hyperammonemia Due To Ornithine Carbamoyltransferase Deficiency
Deficiency, Ornithine Carbamoyltransferase

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12607	SEC14L2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SEC14L2	VGNC	VGNC:107721
Macaca mulatta	SEC14L2	VGNC	VGNC:108034
Mus musculus	SEC14L2	MGD	MGI:1915065
Rattus norvegicus	SEC14L2	RGD	RGD:621779

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