LILRA4 - leukocyte immunoglobulin like receptor A4 Gene

Homo sapiens

Also known as ILT7; CD85g

Gene ID: 23547 | Gene type: protein coding

About LILRA4

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:54,333,185-54,339,162 (from NCBI)

This gene has 3 transcripts (splice variants), 1 gene allele, 300 orthologues and 25 paralogues. Biased expression in spleen (RPKM 5.0), lymph node (RPKM 4.4) and 6 other tissues.

Summary

This gene encodes an immunoglobulin-like cell surface protein that is expressed predominantly on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response. Expression of this gene is downregulated by interleukin 3 (IL3). This gene is one of a cluster of highly related genes located at chromosomal region 19q13.4. [provided by RefSeq, Jan 2015]

LILRA4 Products(1)

mRNA	Protein	Name
NM_012276.5	NP_036408.4	leukocyte immunoglobulin-like receptor subfamily A member 4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables coreceptor activity	IDA IDA: Inferred from direct assay	16735691	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19564354	GOA
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	16735691	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Fc-epsilon receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16735691	GOA
involved in negative regulation of interferon-alpha production	IMP IMP: Inferred from mutant phenotype	16735691	GOA
involved in negative regulation of toll-like receptor 7 signaling pathway	IMP IMP: Inferred from mutant phenotype	16735691	GOA
involved in negative regulation of toll-like receptor 9 signaling pathway	IMP IMP: Inferred from mutant phenotype	16735691	GOA
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	16735691	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Fc-epsilon receptor I complex	IDA IDA: Inferred from direct assay	16735691	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	16735691	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LILRA4 Protein Structure

Ig_2

Ig_3

Ig_2

Ig_3

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

leukocyte immunoglobulin-like receptor subfamily A member 4

CD85 antigen-like family member G

LILRA4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	LILRA4	P59901	BST2	Homo sapiens	Q10589	Solid Phase Assay	19564354
Intra	LILRA4	P59901	BST2	Homo sapiens	Q10589	SPR	19564354

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LILRA4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77441	LILRA4/ILT-7/CD85g Protein, Human (HEK293, His)	P59901-1 (E24-N446)	≥95%
HY-P78480	LILRA4/ILT-7/CD85g Protein, Human (HEK293, His-Avi)	P59901 (E24-N446)	≥95%

Related Diseases

Diseases

Alias

Pitt-Hopkins Syndrome

PTHS	Encephalopathy, Severe Epileptic, With Autonomic Dysfunction
Mental Retardation, Syndromal, With Intermittent Hyperventilation	Intellectual Disability, Wide Mouth, Distinctive Facial Features, And Intermittent Hyperventilation Followed By Apnea
Pitt Hopkins Syndrome	Phs
Encephalopathy Severe Epileptic With Autonomic Dysfunction

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07648	LILRA4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca fascicularis	LILRA4	NCBI
Others	LILRA4	NCBI

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