OPN3 - opsin 3 Gene

Homo sapiens

Also known as ECPN; PPP1R116

Gene ID: 23596 | Gene type: protein coding

About OPN3

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:241,593,124-241,640,369 (from NCBI)

This gene has 7 transcripts (splice variants), 193 orthologues and 9 paralogues. Broad expression in placenta (RPKM 19.5), lung (RPKM 11.0) and 24 other tissues.

Summary

Opsins are members of the guanine nucleotide-binding protein (G protein)-coupled receptor superfamily. In addition to the visual opsins, mammals possess several photoreceptive non-visual opsins that are expressed in extraocular tissues. This gene, opsin 3, is strongly expressed in brain and testis and weakly expressed in liver, placenta, heart, lung, skeletal muscle, kidney, and pancreas. The gene may also be expressed in the retina. The protein has the canonical features of a photoreceptive opsin protein. [provided by RefSeq, Jul 2008]

OPN3 Products(3)

mRNA	Protein	Name
NM_001381855.1	NP_001368784.1	opsin-3 isoform 2
NM_001381856.1	NP_001368785.1	opsin-3 isoform 3
NM_014322.3	NP_055137.2	opsin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 11-cis retinal binding	IDA IDA: Inferred from direct assay	31097585	GOA
enables all-trans retinal binding	IDA IDA: Inferred from direct assay	31097585	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	31097585	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to UV-A	IDA IDA: Inferred from direct assay	31380578	GOA
involved in keratinocyte differentiation	IMP IMP: Inferred from mutant phenotype	30168605	GOA
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	31730232	GOA
involved in negative regulation of melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	31097585	GOA
involved in positive regulation of melanin biosynthetic process	IMP IMP: Inferred from mutant phenotype	28842328	GOA
involved in response to blue light	IDA IDA: Inferred from direct assay	30168605	GOA
involved in response to blue light	IMP IMP: Inferred from mutant phenotype	28842328	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30168605	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	30168605	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OPN3 Protein Structure

7tm_1

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

opsin-3

encephalopsin

OPN3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	OPN3	Q9H1Y3	MC1R	Homo sapiens	Q01726	Confocal	31097585
Intra	OPN3	Q9H1Y3	MC1R	Homo sapiens	Q01726	Anti Tag CoIP	31097585
Intra	OPN3	Q9H1Y3	MC1R	Homo sapiens	Q01726	Anti Bait CoIP	31097585

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09798	OPN3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OPN3	VGNC	VGNC:75400
Rattus norvegicus	OPN3	RGD	RGD:1594385
Felis catus	OPN3	VGNC	VGNC:107908
Mus musculus	OPN3	MGD	MGI:1338022
Canis familiaris	OPN3	VGNC	VGNC:44130

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