MKRN1 - makorin ring finger protein 1 Gene

Homo sapiens

Also known as RNF61

Gene ID: 23608 | Gene type: protein coding

About MKRN1

Cytogenetic location: 7q34 Genomic coordinates (GRCh38): 7:140,453,033-140,479,569 (from NCBI)

This gene has 16 transcripts (splice variants), 129 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 50.0), testis (RPKM 49.4) and 25 other tissues.

Summary

This gene encodes a protein that belongs to a novel class of zinc finger proteins. The encoded protein functions as a transcriptional co-regulator, and as an E3 ubiquitin Ligase that promotes the ubiquitination and proteasomal degradation of target proteins. The protein encoded by this gene is thought to regulate RNA polymerase II-catalyzed transcription. Substrates for this protein's E3 ubiquitin Ligase activity include the capsid protein of the West Nile virus and the catalytic subunit of the Telomerase ribonucleoprotein. This protein controls cell cycle arrest and Apoptosis by regulating p21, a cell cycle regulator, and the tumor suppressor protein p53. Pseudogenes of this gene are present on chromosomes 1, 3, 9, 12 and 20, and on the X chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2014]

MKRN1 Products(3)

mRNA	Protein	Name
NM_001145125.2	NP_001138597.1	E3 ubiquitin-protein ligase makorin-1 isoform 2
NM_001291663.2	NP_001278592.1	E3 ubiquitin-protein ligase makorin-1 isoform 3
NM_013446.4	NP_038474.2	E3 ubiquitin-protein ligase makorin-1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19536131	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	19536131	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein polyubiquitination	IDA IDA: Inferred from direct assay	19536131	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MKRN1 Protein Structure

zf-CCCH

zf-C3HC4

0
100
200
300
400
482 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase makorin-1

RING finger protein 61

MKRN1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MKRN1	Q9UHC7	BYSL	Homo sapiens	Q13895	Y2H Array	32296183
Intra	MKRN1	Q9UHC7	TP53	Homo sapiens	P04637	Anti Tag CoIP	19536131
Intra	MKRN1	Q9UHC7	CDKN1A	Homo sapiens	P38936	Anti Tag CoIP	19536131
Intra	MKRN1	Q9UHC7	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

West Nile Virus

West Nile Virus, Susceptibility To	Wnv
Wnv, Susceptibility To	West Nile Viral Infection
Encephalitis, West Nile Fever	West Nile Fever

Cerebellar Astrocytoma

Astrocytoma Of Cerebellum

Pilomyxoid Astrocytoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08479	MKRN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MKRN1	RGD	RGD:1303251
Mus musculus	MKRN1	MGD	MGI:1859353
Bos taurus	MKRN1	VGNC	VGNC:107229
Macaca mulatta	MKRN1	VGNC	VGNC:81476
Felis catus	MKRN1	VGNC	VGNC:80625

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