MKRN2 - makorin ring finger protein 2 Gene

Homo sapiens

Also known as RNF62; HSPC070

Gene ID: 23609 | Gene type: protein coding

About MKRN2

Cytogenetic location: 3p25.2 Genomic coordinates (GRCh38): 3:12,557,087-12,583,713 (from NCBI)

This gene has 14 transcripts (splice variants), 210 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 30.6), thyroid (RPKM 16.5) and 25 other tissues.

Summary

This gene encodes a probable E3 ubiquitin Ligase containing several zinc finger domains, that is a member of the makorin RING zinc-finger protein family. This gene overlaps the v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) gene in an antisense orientation and may have a co-regulatory function with RAF1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]

MKRN2 Products(2)

mRNA	Protein	Name
NM_001271707.2	NP_001258636.1	E3 ubiquitin-protein ligase makorin-2 isoform 2
NM_014160.5	NP_054879.3	E3 ubiquitin-protein ligase makorin-2 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17500595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MKRN2 Protein Structure

zf-CCCH_2

zf-CCCH

zf-C3HC4

zf-CCCH_2

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase makorin-2

RING finger protein 62

MKRN2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MKRN2	Q9H000	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Array	32814053
Intra	MKRN2	Q9H000	GTF3C3	Homo sapiens	Q9Y5Q9	Validated Y2H	32814053
Intra	MKRN2	Q9H000	GTF3C3	Homo sapiens	Q9Y5Q9	Y2H Pooling	32814053
Cross	MKRN2	Q9H000	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Y2H Pooling	22046132
Cross	MKRN2	Q9H000	P0C6X7-PRO_0000037311	Human SARS coronavirus	P0C6X7-PRO_0000037311	Lumier	22046132
Intra	MKRN2	Q9H000	HTT	Homo sapiens	P42858	Y2H	17500595
Intra	MKRN2	Q9H000	UBE2D1	Homo sapiens	P51668	Y2H Array	25416956
Intra	MKRN2	Q9H000	UBE2D1	Homo sapiens	P51668	Validated Y2H	25416956
Intra	MKRN2	Q9H000	UBE2D4	Homo sapiens	Q9Y2X8	Validated Y2H	32296183
Intra	MKRN2	Q9H000	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Array	25416956
Intra	MKRN2	Q9H000	UBE2D4	Homo sapiens	Q9Y2X8	Y2H Prey Pooling	25416956
Intra	MKRN2	Q9H000	DR1	Homo sapiens	Q01658	Validated Y2H	32814053
Intra	MKRN2	Q9H000	DR1	Homo sapiens	Q01658	Y2H Array	32814053
Intra	MKRN2	Q9H000	DR1	Homo sapiens	Q01658	Y2H Pooling	32814053
Intra	MKRN2	Q9H000	e9kl35_human	Homo sapiens	E9KL35	Validated Y2H	25416956
Intra	MKRN2	Q9H000	AIRIM	Homo sapiens	Q9NX04	Y2H Array	25416956
Intra	MKRN2	Q9H000	AIRIM	Homo sapiens	Q9NX04	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Oligoasthenoteratozoospermia

Oat	Oligoasthenoteratospermia

Central Precocious Puberty

Cpp	Gonadotropin-Dependant Precocious Puberty
Gonadotropin-Dependent Precocious Puberty	Precocious Puberty, Central

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08480	MKRN2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MKRN2	VGNC	VGNC:68266
Rattus norvegicus	MKRN2	RGD	RGD:1310618
Mus musculus	MKRN2	MGD	MGI:1914277
Bos taurus	MKRN2	VGNC	VGNC:55064
Canis familiaris	MKRN2	VGNC	VGNC:43252
Macaca mulatta	MKRN2	VGNC	VGNC:74878

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