CA14 - carbonic anhydrase 14 Gene

Homo sapiens

Also known as CAXiV

Gene ID: 23632 | Gene type: protein coding

About CA14

Cytogenetic location: 1q21.2 Genomic coordinates (GRCh38): 1:150,257,774-150,265,078 (from NCBI)

This gene has 6 transcripts (splice variants), 210 orthologues and 14 paralogues. Biased expression in brain (RPKM 3.3), skin (RPKM 1.4) and 12 other tissues.

Summary

Carbonic anhydrases (CAs) are a large family of zinc metalloenzymes that catalyze the reversible hydration of carbon dioxide. They participate in a variety of biological processes, including respiration, calcification, acid-base balance, bone resorption, and the formation of aqueous humor, cerebrospinal fluid, saliva, and gastric acid. They show extensive diversity in tissue distribution and in their subcellular localization. CA XIV is predicted to be a type I membrane protein and shares highest sequence similarity with the other transmembrane CA isoform, CA XII; however, they have different patterns of tissue-specific expression and thus may play different physiologic roles. [provided by RefSeq, Jul 2008]

CA14 Products(1)

mRNA	Protein	Name
NM_012113.3	NP_036245.1	carbonic anhydrase 14 precursor

CA14 Protein Structure

Carb_anhydrase

0
100
200
300
337 a.a.

Protein Preferred Names

Protein Names

carbonic anhydrase 14

CA-XIV

Recombinant CA14 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7727	Carbonic Anhydrase 14 Protein, Human (His)	Q9ULX7 (G19-M290)	≥95%
HY-P72867	Carbonic Anhydrase 14 Protein, Human (HEK293, His)	Q9ULX7/NP_036245.1 (A16-M290)	≥95%

Related Diseases

Diseases

Alias

Malignant Gastric Teratoma

Malignant Teratoma Of Stomach

Immature Gastric Teratoma

Malignant Gastric Germ Cell Tumor

Germ Cell Tumor Of The Stomach	Germ Cell Tumour Of The Stomach
Malignant Gastric Germ Cell Tumour

Intracranial Hypertension, Idiopathic

Pseudotumor Cerebri	Idiopathic Intracranial Hypertension
Benign Intracranial Hypertension	Iih
Benign Intracran. Hypt.

Gastric Teratoma

Teratoma Of Stomach

Osteopetrosis, Autosomal Recessive 3

Osteopetrosis With Renal Tubular Acidosis	Marble Brain Disease
OPTB3	Guibaud-Vainsel Syndrome
Carbonic Anhydrase Ii Deficiency	Osteopetrosis, Autosomal Recessive 3, With Renal Tubular Acidosis
Autosomal Recessive Osteopetrosis 3	Carbonic Anhydrase 2 Deficiency
Autosomal Recessive Osteopetrosis 3 With Renal Tubular Acidosis	Osteopetrosis Autosomal Recessive 3
Autosomal Recessive Osteopetrosis Type 3	Guibaud Vainsel Syndrome
Mixed Rta	Mixed Renal Tubular Acidosis
Renal Tubular Acidosis Type 3	Carbonic Anhydrase Ii Deficiency Syndrome
Carbonic Anhydrase Ii Variant	Osteopetrosis, Autosomal Recessive, Type 3
Carbonic Anhydrase 2

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01767	CA14 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CA14	MGD	MGI:1344341
Bos taurus	CA14	VGNC	VGNC:26652
Macaca mulatta	CA14	VGNC	VGNC:70489
Rattus norvegicus	CA14	RGD	RGD:1599277
Felis catus	CA14	VGNC	VGNC:60244
Canis familiaris	CA14	VGNC	VGNC:38609
Others	CA14	NCBI

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