EID1 - EP300 interacting inhibitor of differentiation 1 Gene

Homo sapiens

Also known as CRI1; EID-1; RBP21; PTD014; C15orf3; PNAS-22; IRO45620

Gene ID: 23741 | Gene type: protein coding

About EID1

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:48,878,134-48,880,173 (from NCBI)

This gene has 2 transcripts (splice variants), 88 orthologues and 2 paralogues.

Summary

Enables Histone Acetyltransferase binding activity and Histone Acetyltransferase regulator activity. Involved in cell differentiation and negative regulation of transcription, DNA-templated. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasmic ribonucleoprotein granule and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

EID1 Products(1)

mRNA	Protein	Name
NM_014335.3	NP_055150.1	EP300-interacting inhibitor of differentiation 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables histone acetyltransferase binding	IDA IDA: Inferred from direct assay	11073990	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11073990	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell differentiation	IDA IDA: Inferred from direct assay	11073989	GOA
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11073990	GOA
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11073990	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

EP300-interacting inhibitor of differentiation 1

21 kDa pRb-associated protein

EID1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	EID1	Q9Y6B2	Ndn	Mus musculus	P25233	Anti Bait CoIP	18557765
Cross	EID1	Q9Y6B2	Ndn	Mus musculus	P25233	Anti Tag CoIP	18557765
Intra	EID1	Q9Y6B2	FBXO21	Homo sapiens	O94952	Anti Tag CoIP	26085330
Intra	EID1	Q9Y6B2	FBXO21	Homo sapiens	O94952	Anti Tag CoIP	33961781
Intra	EID1	Q9Y6B2	NDN	Homo sapiens	Q99608	Anti Tag CoIP	32529326
Intra	EID1	Q9Y6B2	NDN	Homo sapiens	Q99608	Anti Tag CoIP	21364888

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Hyperhidrosis, Gustatory

Frey Syndrome	Gustatory Sweating
Auriculotemporal Nerve Syndrome	Gustatory Hyperhidrosis
Frey'S Syndrome	Sweating, Gustatory
HYPRG	Baillarger Syndrome
Hyperhidrosis Gustatory	Auriculotemporal Syndrome

Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome	PWS
Willi-Prader Syndrome	Prader-Willi Syndrome Due To Translocation
Prader-Willi Syndrome Due To Imprinting Mutation	Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Prader Willi Syndrome	Upd(15)Mat

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04234	EID1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	EID1	VGNC	VGNC:40252
Rattus norvegicus	EID1	RGD	RGD:1562702
Mus musculus	EID1	MGD	MGI:1889651

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