1. Gene
  2. Sigirr - single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Gene

Sigirr - single immunoglobulin and toll-interleukin 1 receptor (TIR) domain Gene

Mus musculus

Also known as TIR8

Gene ID: 24058 | Gene type: protein coding

About Sigirr

Summary

Involved in acute-phase response; negative regulation of chemokine production; and negative regulation of cytokine-mediated signaling pathway. Predicted to be located in membrane. Is expressed in genitourinary system. Orthologous to human SIGIRR (single Ig and TIR domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Sigirr Products(2)

mRNA Protein Name
NM_001355055.1 NP_001341984.1 single Ig IL-1-related receptor
NM_023059.3 NP_075546.2 single Ig IL-1-related receptor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
involved in acute-phase response IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of cytokine-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12925853 MGI
involved in negative regulation of interleukin-1-mediated signaling pathway IMP
IMP: Inferred from mutant phenotype
12925853 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

single Ig IL-1-related receptor

single Ig IL-1 receptor related protein

single Ig IL-1R-related molecule

single Ig IL-1R-related protein

single immunoglobulin domain-containing IL1R-related protein

toll/interleukin-1 receptor 8

Recombinant Sigirr Proteins

Cat. No. Product Name Accession Purity
HY-P74547 SIGIRR Protein, Mouse (HEK293, His) Q9JLZ8 (M1-H117) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Sigirr NCBI NCBI:59307