SIGIRR - single Ig and TIR domain containing Gene

Homo sapiens

Also known as TIR8; IL-1R8

Gene ID: 59307 | Gene type: protein coding

About SIGIRR

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:405,716-417,397 (from NCBI)

This gene has 22 transcripts (splice variants), 176 orthologues and 10 paralogues. Ubiquitous expression in spleen (RPKM 19.3), kidney (RPKM 16.8) and 25 other tissues.

Summary

Predicted to enable NAD+ nucleosidase activity. Involved in negative regulation of DNA-binding transcription factor activity. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

SIGIRR Products(3)

mRNA	Protein	Name
NM_001135053.2	NP_001128525.1	single Ig IL-1-related receptor
NM_001135054.2	NP_001128526.1	single Ig IL-1-related receptor
NM_021805.3	NP_068577.2	single Ig IL-1-related receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12925853	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Toll signaling pathway	IMP IMP: Inferred from mutant phenotype	12925853	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in membrane	IMP IMP: Inferred from mutant phenotype	10346978	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SIGIRR Protein Structure

TIR

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

single Ig IL-1-related receptor

single Ig IL-1R-related molecule

SIGIRR Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SIGIRR	Q6IA17	PALM3	Homo sapiens	A6NDB9	Y2H	21187075
Intra	SIGIRR	Q6IA17	PALM3	Homo sapiens	A6NDB9	Anti Tag CoIP	21187075

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SIGIRR Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76064	SIGIRR Protein, Human (HEK293, Fc)	Q6IA17-1 (M1-H118)	≥95%
HY-P76065	SIGIRR Protein, Human (HEK293, His)	Q6IA17 (M1-H118)	≥95%

Related Diseases

Diseases

Alias

Progressive Myoclonus Epilepsy 8

Emp8	Pme Type 8
Progressive Myoclonic Epilepsy Due To Cers1 Deficiency	Progressive Myoclonus Epilepsy Type 8

Loeffler Syndrome

Loeffler'S Pneumonia	Loffler'S Syndrome
Simple Pulmonary Eosinophilia

Inflammatory Diarrhea

Chemical Colitis

Central Nervous System Tuberculosis

Intracranial Tuberculoma	Tuberculoma Of Brain
Tuberculosis Of Meninges And Central Nervous System	Tuberculous Abscess Of Brain
Tuberculoma, Intracranial	Tuberculosis, Central Nervous System

Perinatal Necrotizing Enterocolitis

Necrotizing Enterocolitis	Enterocolitis Necrotizing
Enterocolitis, Necrotizing	Necrotizing Enterocolitis In Fetus Or Newborn
Perinatal Necrotising Enterocolitis	Pseudomembranous Enterocolitis In Newborn
Nec

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12896	SIGIRR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	SIGIRR	VGNC	VGNC:65140
Canis familiaris	SIGIRR	VGNC	VGNC:46167
Mus musculus	SIGIRR	MGD	MGI:1344402
Rattus norvegicus	SIGIRR	RGD	RGD:1306732
Bos taurus	SIGIRR	VGNC	VGNC:34616
Others	SIGIRR	NCBI

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