KIF4A - kinesin family member 4A Gene

Homo sapiens

Also known as KIF4; KIF4G1; MRX100; XLID100

Gene ID: 24137 | Gene type: protein coding

About KIF4A

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:70,290,104-70,420,886 (from NCBI)

This gene has 2 transcripts (splice variants), 192 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in bone marrow (RPKM 4.3), lymph node (RPKM 2.9) and 14 other tissues.

Summary

This gene encodes a member of the Kinesin 4 subfamily of Kinesin related proteins. The encoded protein is an ATP dependent microtubule-based motor protein that is involved in the intracellular transport of membranous organelles. This protein also associates with condensed chromosome arms and may be involved in maintaining chromosome integrity during mitosis. This protein may also be involved in the organization of the central spindle prior to cytokinesis. A pseudogene of this gene is found on chromosome X.[provided by RefSeq, Mar 2010]

KIF4A Products(1)

mRNA	Protein	Name
NM_012310.5	NP_036442.3	chromosome-associated kinesin KIF4A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16431929	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in mitotic cytokinesis	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic spindle midzone assembly	IMP IMP: Inferred from mutant phenotype	15843429	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in midbody	IDA IDA: Inferred from direct assay	15166316	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF4A Protein Structure

Kinesin

0
200
400
600
800
1000
1232 a.a.

Protein Preferred Names

Protein Names

chromosome-associated kinesin KIF4A

chromokinesin-A

Related Diseases

Diseases

Alias

Intellectual Developmental Disorder, X-Linked 100

XLID100	Mental Retardation, X-Linked 100
Mrx100	Mental Retardation, X-Linked, Type 100

Multicystic Dysplastic Kidney

Multicystic Renal Dysplasia	Multicystic Kidney Dysplasia
Mcdk	Multiple Congenital Cysts Of Kidney
Developmental Multicystic Kidney

Hydrocephalus, Congenital, 1

Hydrocephaly	Ventriculomegaly
Hydrocephalus, Nonsyndromic, Autosomal Recessive 1	HYC1
Congenital Non-Communicating Hydrocephalus	Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly
Congenital Obstructive Hydrocephalus	Hydrocephalus, Non-Syndromic, Autosomal Recessive 1
Hydrocephalus

Hydrocephalus

Hydrocephalus, Nonsyndromic, Autosomal Recessive	Hydrocephalus, X-Linked
Hydrocephalus Adverse Event	Hydrocephaly Nos

Retinoblastoma

RB	Trilateral Retinoblastoma
RB1	Retinoblastoma, Trilateral
Neuroblastoma Of Retina	Rb - Retinoblastoma
Eye Cancer, Retinoblastoma	Retinal Cancer
Retinal Tumor	Glioma, Retinal
Non-Hereditary Retinoblastoma	Childhood Cancer Retinoblastoma
Malignant Neoplasm Of Retina	Retinal Neoplasms

Charcot-Marie-Tooth Disease, Axonal, Type 2dd

CMT2DD	Charcot-Marie-Tooth Neuropathy, Type 2dd
Charcot-Marie-Tooth Disease Type 2dd	Atp1a1-Related Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Atp1a1-Related Cmt2	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2dd
Charcot-Marie-Tooth Disease 2dd

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07288	KIF4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KIF4A	VGNC	VGNC:103830
Rattus norvegicus	KIF4A	RGD	RGD:620526
Mus musculus	KIF4A	MGD	MGI:108389

Name
Email *

	Sorry, but the email address you supplied was invalid.