Pak5 - p21 (RAC1) activated kinase 5 Gene

Mus musculus

Also known as Pak7; PAK-5; PAK-7; 2900083L08Rik

Gene ID: 241656 | Gene type: protein coding

About Pak5

Chromosome 2: 135,923,024-136,229,887 reverse strand.GRCm39:CM000995.3

This gene has 3 transcripts (splice variants), 214 orthologues, 35 paralogues and is associated with 9 phenotypes. Biased expression in CNS E18 (RPKM 6.8), cortex adult (RPKM 6.4) and 5 other tissues.

Summary

Enables protein serine/threonine kinase activity. Acts upstream of or within learning or memory; locomotory behavior; and negative regulation of extrinsic apoptotic signaling pathway. Located in mitochondrion. Is active in synapse. Is expressed in brain. Orthologous to human PAK5 (p21 (RAC1) activated kinase 5). [provided by Alliance of Genome Resources, Apr 2022]

Pak5 Products(3)

mRNA	Protein	Name
NM_172858.2	NP_766446.2	serine/threonine-protein kinase PAK 5
NM_001360384.1	NP_001347313.1	serine/threonine-protein kinase PAK 5
NM_001360382.1	NP_001347311.1	serine/threonine-protein kinase PAK 5

Pak5 Protein Structure

CRIB_PAK_like

STKc_PAK5

0
200
400
600
719 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 5

p21 (RAC1) activated kinase 7	p21 protein (Cdc42/Rac)-activated kinase 7
p21-activated kinase 5	p21-activated kinase 7
serine/threonine-protein kinase PAK 7

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.68%	Phase 2
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Unkown
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pak5	NCBI	NCBI:57144

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