PAK5 - p21 (RAC1) activated kinase 5 Gene

Homo sapiens

Also known as PAK7

Gene ID: 57144 | Gene type: protein coding

About PAK5

Cytogenetic location: 20p12.2 Genomic coordinates (GRCh38): 20:9,537,370-9,839,076 (from NCBI)

This gene has 3 transcripts (splice variants), 214 orthologues and 35 paralogues. Biased expression in brain (RPKM 4.1), adrenal (RPKM 1.0) and 1 other tissue.

Summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

PAK5 Products(7)

mRNA	Protein	Name
NM_020341.5	NP_065074.1	serine/threonine-protein kinase PAK 5
XM_017027960.2	XP_016883449.1	serine/threonine-protein kinase PAK 5 isoform X1
NM_177990.4	NP_817127.1	serine/threonine-protein kinase PAK 5
XM_017027965.2	XP_016883454.1	serine/threonine-protein kinase PAK 5 isoform X1
XM_017027962.2	XP_016883451.1	serine/threonine-protein kinase PAK 5 isoform X1
XM_017027961.2	XP_016883450.1	serine/threonine-protein kinase PAK 5 isoform X1
XM_017027964.2	XP_016883453.1	serine/threonine-protein kinase PAK 5 isoform X1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19060904	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PAK5 Protein Structure

PBD

Pkinase

0
200
400
600
719 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase PAK 5

PAK-5	PAK-7
p21 (RAC1) activated kinase 7	p21 protein (Cdc42/Rac)-activated kinase 7
p21(CDKN1A)-activated kinase 7	p21-activated kinase 5
p21-activated kinase 7	p21CDKN1A-activated kinase 7
protein kinase PAK5	serine/threonine-protein kinase PAK 7
serine/threonine-protein kinase PAK7

PAK5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	PAK5	Q9P286	INKA1	Homo sapiens	Q96EL1	Validated Y2H	25416956
Intra	PAK5	Q9P286	INKA1	Homo sapiens	Q96EL1	Y2H Array	25416956
Intra	PAK5	Q9P286	INKA1	Homo sapiens	Q96EL1	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	ATPAF2	Homo sapiens	Q8N5M1	Y2H Array	25416956
Intra	PAK5	Q9P286	ATPAF2	Homo sapiens	Q8N5M1	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	CRBN	Homo sapiens	Q96SW2	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	YWHAE	Homo sapiens	P62258	Crosslink	36931259
Intra	PAK5	Q9P286	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	PAK5	Q9P286	UXT	Homo sapiens	Q9UBK9	Validated Y2H	25416956
Intra	PAK5	Q9P286	EXOSC1	Homo sapiens	Q9Y3B2	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	EXOSC1	Homo sapiens	Q9Y3B2	Y2H Array	25416956
Intra	PAK5	Q9P286	CCNG1	Homo sapiens	P51959	Validated Y2H	25416956
Intra	PAK5	Q9P286	CCNG1	Homo sapiens	P51959	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	PAK5	Q9P286	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	PAK5	Q9P286	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	PAK5	Q9P286	EMD	Homo sapiens	P50402	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	PECAM1	Homo sapiens	P16284	Validated Y2H	32814053
Intra	PAK5	Q9P286	PECAM1	Homo sapiens	P16284	Y2H Array	32814053
Intra	PAK5	Q9P286	PECAM1	Homo sapiens	P16284	Y2H Pooling	32814053
Intra	PAK5	Q9P286	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	PAK5	Q9P286	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	PAK5	Q9P286	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	PAK5	Q9P286	LENG1	Homo sapiens	Q96BZ8	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	SORBS3	Homo sapiens	O60504	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	SORBS3	Homo sapiens	O60504	Validated Y2H	25416956
Intra	PAK5	Q9P286	ARMC7	Homo sapiens	Q9H6L4	Y2H Prey Pooling	25416956
Intra	PAK5	Q9P286	GCC1	Homo sapiens	Q96CN9	Validated Y2H	25416956
Intra	PAK5	Q9P286	CARD9	Homo sapiens	Q9H257	Y2H Array	31515488
Intra	PAK5	Q9P286	CARD9	Homo sapiens	Q9H257	Validated Y2H	25416956
Intra	PAK5	Q9P286	CARD9	Homo sapiens	Q9H257	Y2H Array	25416956
Intra	PAK5	Q9P286	CDC42	Homo sapiens	P60953	Pull Down	32707033
Intra	PAK5	Q9P286	CDC42	Homo sapiens	P60953	Y2H Pooling	20936779

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant PAK5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P72065	PAK5 Protein, Human (Baculovirus, His)	Q8TB93 (M1-Q293)	≥95%

Related Diseases

Diseases

Alias

Breast Large Cell Neuroendocrine Carcinoma

Trichorhinophalangeal Syndrome, Type I

Trichorhinophalangeal Dysplasia Type I	TRPS1
Trichorhinophalangeal Syndrome Type I	Trps I
Trichorhinophalangeal Syndrome Type 1	Type I Trichorhinophalangeal Syndrome
Giedion Syndrome	Trp Syndrome
Tricho-Rhino-Phalangeal Syndrome 1	Trichorhinophalangeal Syndrome, Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Phase
HY-15323	PRT062607 Hydrochloride	Inhibitor	98.07%	Phase 2
HY-13007	PF-3758309	Inhibitor	99.84%	Phase 1
HY-13007B	PF-3758309 dihydrochloride	Inhibitor	/	Phase 1
HY-13007A	PF-3758309 hydrochloride	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15324	PRT062607 acetate	Inhibitor	99.83%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PAK5	VGNC	VGNC:81138
Mus musculus	PAK5	MGD	MGI:1920334
Rattus norvegicus	PAK5	RGD	RGD:1312009
Macaca mulatta	PAK5	VGNC	VGNC:97111
Canis familiaris	PAK5	VGNC	VGNC:53544
Others	PAK5	NCBI

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