Agtr1a - angiotensin II receptor, type 1a Gene

Rattus norvegicus

Also known as AT1; AT1A; AT1R; Agtr1

Gene ID: 24180 | Gene type: protein coding

About Agtr1a

Summary

Enables D1 Dopamine Receptor binding activity; angiotensin type I receptor activity; and protein kinase binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; cation homeostasis; and response to glucocorticoid. Located in several cellular components, including basolateral plasma membrane; organelle outer membrane; and recycling endosome. Used to study several diseases, including asthma; chronic kidney disease; congestive heart failure; hypertension (multiple); and nephritis. Biomarker of several diseases, including anti-basement membrane glomerulonephritis; artery disease (multiple); glomerulosclerosis (multiple); hyperinsulinism; and placental insufficiency. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease; COVID-19; artery disease (multiple); chronic kidney disease; and sarcoidosis. Orthologous to human AGTR1 (angiotensin II receptor type 1). [provided by Alliance of Genome Resources, Apr 2022]

Agtr1a Products(2)

mRNA	Protein	Name
NM_030985.4	NP_112247.2	type-1 angiotensin II receptor A
NM_030985.4	NP_112247.2	type-1 angiotensin II receptor A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	22193384	RGD
enables angiotensin type I receptor activity	IDA IDA: Inferred from direct assay	2041570	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14559250	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	9287353	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	9092554	RGD
involved in activation of Janus kinase activity	IMP IMP: Inferred from mutant phenotype	9314843	RGD
involved in angiotensin-activated signaling pathway	IMP IMP: Inferred from mutant phenotype	21769867	RGD
involved in cellular response to dexamethasone stimulus	IDA IDA: Inferred from direct assay	17537984	RGD
involved in dopamine biosynthetic process	IMP IMP: Inferred from mutant phenotype	20097214	RGD
involved in drinking behavior	IMP IMP: Inferred from mutant phenotype	9622148	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11906170	RGD
involved in positive regulation of angiogenesis	IMP IMP: Inferred from mutant phenotype	32324784	RGD
involved in positive regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	20702798	RGD
involved in positive regulation of branching involved in ureteric bud morphogenesis	IMP IMP: Inferred from mutant phenotype	17537984	RGD
involved in positive regulation of calcium ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	15569855	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	22645419	RGD
involved in positive regulation of receptor recycling	IDA IDA: Inferred from direct assay	14559250	RGD
involved in positive regulation of superoxide anion generation	IMP IMP: Inferred from mutant phenotype	21076237	RGD
involved in regulation of pH	IDA IDA: Inferred from direct assay	11906170	RGD
involved in renin-angiotensin regulation of aldosterone production	IMP IMP: Inferred from mutant phenotype	21318332	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	18252761	RGD
involved in response to angiotensin	IEP IEP: Inferred from expression pattern	8986922	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	7594440	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	12810582	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15544836	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	9095078	RGD
involved in vasoconstriction	IMP IMP: Inferred from mutant phenotype	20955746	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	14559250	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	12110004	RGD
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	14559250	RGD
located in dendrite	IDA IDA: Inferred from direct assay	15590154	RGD
located in organelle outer membrane	IDA IDA: Inferred from direct assay	15590154	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	14559250	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	14559250	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

type-1 angiotensin II receptor A

type-1A angiotensin II receptor

AT1 receptor A	angiotensin II type-1 receptor A
angiotensin II type-1A receptor	angiotensin receptor 1a
vascular type-1 angiotensin II receptor

Agtr1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Agtr1	P25095	AGT	Homo sapiens	P01019	Saturation Binding	18202720

Cross: Cross-species interaction Intra: Intraspecies interaction

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