2. Gene
  3. Pde5a - phosphodiesterase 5A, cGMP-specific Gene

Pde5a - phosphodiesterase 5A, cGMP-specific Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Cn5n; Pde5; Cgbpde; PDE5a2; Pde5a1

Gene ID: 242202 | Gene type: protein coding

About Pde5a

Chromosome 3: 122,522,596-122,653,023 forward strand.GRCm39:CM000996.3

This gene has 4 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 49.4), lung adult (RPKM 12.8) and 6 other tissues.

Summary

Enables 3',5'-cyclic-nucleotide phosphodiesterase activity and cGMP binding activity. Involved in positive regulation of MAP kinase activity; regulation of muscle system process; and relaxation of cardiac muscle. Acts upstream of or within several processes, including cGMP catabolic process; negative regulation of T cell proliferation; and positive regulation of oocyte development. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in IgA glomerulonephritis. Orthologous to human PDE5A (phosphodiesterase 5A). [provided by Alliance of Genome Resources, Apr 2022]

Pde5a Products(2)

mRNA Protein Name
NM_001409793.1 NP_001396722.1 cGMP-specific 3',5'-cyclic phosphodiesterase isoform 2
NM_153422.3 NP_700471.2 cGMP-specific 3',5'-cyclic phosphodiesterase isoform 1

Pde5a Protein Structure

GAF

GAF: smart00065 (153 - 310)

GAF

GAF: smart00065 (336 - 502)

PDEase_I

PDEase_I: pfam00233 (601 - 835)

  • 0
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  • 800
  • 865 a.a.
Protein Preferred Names Protein Names

cGMP-specific 3',5'-cyclic phosphodiesterase

cGMP-binding cGMP-specific phosphodiesterase

Recombinant Pde5a Proteins

Cat. No. Product Name Accession Purity
HY-P71591 cGB-PDE Protein, Mouse (Myc, His) Q8CG03 (D154-N320) ≥95%

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1343 Robustine Inhibitor 99.97% Unkown
HY-106230A Dasantafil Inhibitor 98.35% Unkown
HY-161851 MDL3 Inhibitor / Unkown
HY-RS10227 PDE5A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10228 Pde5a Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10229 Pde5a Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pde5a NCBI NCBI:8654