Epo - erythropoietin Gene

Rattus norvegicus

Gene ID: 24335 | Gene type: protein coding

About Epo

Summary

Predicted to enable cytokine activity; erythropoietin receptor binding activity; and protein kinase activator activity. Involved in several processes, including positive regulation of ERK1 and ERK2 cascade; positive regulation of activated T cell proliferation; and response to dexamethasone. Located in cell body and extracellular space. Used to study retinal detachment and visual epilepsy. Biomarker of cholangiocarcinoma; eye disease (multiple); transient cerebral ischemia; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); diabetic angiopathy; familial erythrocytosis 5; ischemia (multiple); and neurodegenerative disease (multiple). Orthologous to human EPO (erythropoietin). [provided by Alliance of Genome Resources, Apr 2022]

Epo Products(1)

mRNA	Protein	Name
NM_017001.2	NP_058697.1	erythropoietin precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in acute-phase response	IEP IEP: Inferred from expression pattern	19840250	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	21749867	RGD
involved in positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	21649646	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	21749867	RGD
involved in positive regulation of neuron differentiation	IDA IDA: Inferred from direct assay	12876482	RGD
involved in positive regulation of neuron projection development	IDA IDA: Inferred from direct assay	22469063	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	15470751	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	21540288	RGD
involved in response to electrical stimulus	IEP IEP: Inferred from expression pattern	19185286	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	15784734	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19768476	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	19497871	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	9321887	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9321887	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	19136608	RGD
involved in response to salt stress	IEP IEP: Inferred from expression pattern	16815869	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	15778925	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	9027729	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body	IDA IDA: Inferred from direct assay	17554621	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	15470751	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

erythropoietin

Recombinant Epo Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73040	Erythropoietin Protein, Rat (sf9, His)	P29676-1 (A27-R192)	≥95%

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-12654	Molidustat	Inhibitor	98.75%	Phase 3
HY-17029	Epothilone B		99.93%	Phase 3

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145405	C12-200		99.91%	Unkown
HY-13503	Epothilone A		99.75%	Unkown
HY-W062700	STS-E412		99.72%	Unkown
HY-N0403	2,3,4',5-Tetrahydroxystilbene 2-O-β-D-glucoside	Inhibitor	99.78%	Unkown
HY-141625	TRC160334	Inhibitor	≥95.0%	Unkown
HY-141625A	TRC160334 sodium	Inhibitor	/	Unkown
HY-155009	PHD2-IN-1	Inhibitor	/	Unkown
HY-156526	PHD-IN-1	Inhibitor	/	Unkown
HY-161660	DS44470011	Inhibitor	/	Unkown
HY-162438	PHD2-IN-2	Inhibitor	/	Unkown
HY-163839	DS-1093a	Inhibitor	/	Unkown
HY-16444	Sagopilone		/	Unkown
HY-RS04446	EPO Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W747868	Molidustat sodium	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Epo	NCBI	NCBI:2056
Macaca fascicularis	Epo	NCBI	NCBI:101925524
Mus musculus	Epo	NCBI	NCBI:13856
Susscrofa domestica	Epo	NCBI
Macaca mulatta	Epo	NCBI	NCBI:719294

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