2. Gene
  3. Fh - fumarate hydratase Gene

Fh - fumarate hydratase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Fh1

Gene ID: 24368 | Gene type: protein coding

About Fh

Summary

Enables fumarate hydratase activity. Involved in fumarate metabolic process; malate metabolic process; and tricarboxylic acid cycle. Located in mitochondrion. Human ortholog(s) of this gene implicated in fumarase deficiency and lung non-small cell carcinoma. Orthologous to human FH (fumarate hydratase). [provided by Alliance of Genome Resources, Apr 2022]

Fh Products(1)

mRNA Protein Name
NM_017005.2 NP_058701.2 fumarate hydratase, mitochondrial precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables fumarate hydratase activity IMP
IMP: Inferred from mutant phenotype
2914923 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

fumarate hydratase, mitochondrial

fumarase

fumarate hydratase 1

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-34350 2-(Aminomethyl)phenol Inhibitor 99.45% Phase 2
HY-N0842 Bevirimat Inhibitor 99.80% Phase 2
HY-12346 FH1 Inhibitor 98.94% Phase 1
Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-15721 FH535 Inhibitor 98.72% Unkown
HY-D0917 TO-PRO 1 ≥96.0% Unkown
HY-150686 Chitin synthase inhibitor 4 Inhibitor 99.48% Unkown
HY-E70062 α-2,3-Sialyltransferase, pasteurella multocida 90.00% Unkown
HY-160875 GST-FH.1 Inhibitor / Unkown
HY-W028210 O-Phthalimide-C5-acid ≥98.0% Unkown
HY-N8378 Clonostachydiol / Unkown
HY-P2969 Complement factor I / Unkown
HY-RS04930 FH Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-160874 GST-FH.4 Inhibitor / Unkown
HY-N9220 6-Epi-albassitriol Inhibitor / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-P991067 Vensobafusp alfa Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fh NCBI NCBI:2271
Canis familiaris Fh NCBI NCBI:480092
Macaca fascicularis Fh NCBI NCBI:102118371
Mus musculus Fh NCBI NCBI:14193