2. Gene
  3. FST - Fst follistatin Gene

FST - Fst follistatin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as FS; FOL1; Fst-288; RATFOL1

Gene ID: 24373 | Gene type: protein coding

About FST

Summary

Enables heparan sulfate proteoglycan binding activity. Predicted to be involved in hematopoietic progenitor cell differentiation; negative regulation of transcription by RNA polymerase II; and regulation of transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to act upstream of or within several processes, including animal organ development; keratinocyte proliferation; and positive regulation of hair follicle development. Predicted to be located in cytoplasm and nucleus. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (Follistatin). [provided by Alliance of Genome Resources, Apr 2022]

FST Products(1)

mRNA Protein Name
NM_012561.3 NP_036693.1 follistatin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables heparan sulfate proteoglycan binding IDA
IDA: Inferred from direct assay
12867435 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16482217 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to growth factor stimulus IEP
IEP: Inferred from expression pattern
23567549 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
30599193 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

follistatin

activin-binding protein

follistatin-A

FST Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Cross
Fst P21674 INHBA Homo sapiens P08476
Chromatography
16482217
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B1395 Mecamylamine hydrochloride ≥98.0% Yes
HY-B1395A Mecamylamine / Unkown
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101300 Cirazoline hydrochloride Agonist 99.65% Unkown
HY-RS05127 FST Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-147735 GABAA receptor agonist 1 Agonist / Unkown
HY-147736 GABAA receptor agonist 2 Agonist / Unkown
HY-159942 5-HT7R antagonist 3 / Unkown
HY-169394 5-HT1AR agonist 2 / Unkown
HY-P1173 L803-mts Inhibitor / Unkown
HY-W105505 SAMe-1,4-Butanedisulfonate / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens FST NCBI NCBI:10468
Mus musculus FST NCBI NCBI:14313