Ncam1 - neural cell adhesion molecule 1 Gene

Rattus norvegicus

Also known as Cd56; Ncam; N-CAM; NCAMC; NCAM-1; NCAM-C; N-CAM-1

Gene ID: 24586 | Gene type: protein coding

About Ncam1

Summary

Enables LRR domain binding activity and Phosphatase binding activity. Involved in several processes, including axon development; positive regulation of cardiac muscle cell proliferation; and thalamus development. Located in neuronal cell body and plasma membrane. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study middle cerebral artery infarction. Biomarker of Alzheimer's disease; congestive heart failure; hypothyroidism; mental depression; and myocardial infarction. Human ortholog(s) of this gene implicated in bipolar disorder; middle cerebral artery infarction; and pancreatic Cancer. Orthologous to human NCAM1 (neural cell adhesion molecule 1). [provided by Alliance of Genome Resources, Apr 2022]

Ncam1 Products(5)

mRNA	Protein	Name
NM_001395707.1	NP_001382636.1	neural cell adhesion molecule 1 isoform 1 precursor
NM_001395708.1	NP_001382637.1	neural cell adhesion molecule 1 isoform 2 precursor
NM_001395709.1	NP_001382638.1	neural cell adhesion molecule 1 isoform 3 precursor
NM_001395710.1	NP_001382639.1	neural cell adhesion molecule 1 isoform 4 precursor
NM_031521.3	NP_113709.1	neural cell adhesion molecule 1 isoform 5 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables LRR domain binding	IPI IPI: Inferred from physical interaction	15865439	RGD
enables phosphatase binding	IDA IDA: Inferred from direct assay	15865439	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15865439	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16609270	RGD
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	3856258	RGD
involved in behavioral response to ethanol	IEP IEP: Inferred from expression pattern	16207289	RGD
involved in cellular response to ethanol	IDA IDA: Inferred from direct assay	10936176	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	16207289	RGD
involved in cellular response to fluoride	IEP IEP: Inferred from expression pattern	17537562	RGD
involved in cellular response to molecule of bacterial origin	IEP IEP: Inferred from expression pattern	19853610	RGD
involved in learning or memory	IDA IDA: Inferred from direct assay	18702715	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18194217	RGD
involved in medium-term memory	IEP IEP: Inferred from expression pattern	16207289	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	7997264	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	7997264	RGD
involved in multicellular organismal response to stress	IDA IDA: Inferred from direct assay	17429411	RGD
involved in negative regulation of programmed cell death	IMP IMP: Inferred from mutant phenotype	18757519	RGD
involved in neuron development	IDA IDA: Inferred from direct assay	16958105	RGD
involved in peripheral nervous system axon regeneration	IEP IEP: Inferred from expression pattern	15679872	RGD
involved in positive regulation of cardiac muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	19853610	RGD
involved in regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	26821693	RGD
involved in regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	24399412	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	12499861	RGD
involved in response to cocaine	IDA IDA: Inferred from direct assay	16081054	RGD
involved in response to lead ion	IDA IDA: Inferred from direct assay	18499259	RGD
involved in response to morphine	IEP IEP: Inferred from expression pattern	15673448	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	16207289	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	17307340	RGD
involved in thalamus development	IDA IDA: Inferred from direct assay	17292800	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in Schaffer collateral - CA1 synapse	IDA IDA: Inferred from direct assay	7997264	RGD
is active in Schaffer collateral - CA1 synapse	IMP IMP: Inferred from mutant phenotype	7997264	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	10936176	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	2592994	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16216431	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	2592994	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	2592994	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neural cell adhesion molecule 1

Recombinant Ncam1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73749	NCAM-1/CD56 Protein, Rat (HEK293, His)	P13596 (L20-T721)	≥95%

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99372	Lorvotuzumab		99.77%	Phase 2

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09063	NCAM1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ncam1	NCBI	NCBI:4684
Macaca fascicularis	Ncam1	NCBI	NCBI:102144192
Mus musculus	Ncam1	NCBI	NCBI:17967

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