Serpine1 - serpin family E member 1 Gene

Rattus norvegicus

Also known as Pai1; PAI1A; Planh; Pai1aa; RATPAI1A

Gene ID: 24617 | Gene type: protein coding

About Serpine1

Primary_assembly 12: 19,601,272-19,611,657 forward strand.mRatBN7.2:CM026985.1

This gene has 1 transcript (splice variant), 187 orthologues, 49 paralogues and is associated with 150 phenotypes. Biased expression in Heart (RPKM 85.5), Adrenal (RPKM 58.3) and 8 other tissues.

Summary

Enables protease binding activity and serine-type endopeptidase inhibitor activity. Involved in several processes, including cellular response to growth factor stimulus; cellular response to hormone stimulus; and cellular response to organonitrogen compound. Located in chromaffin granule and extracellular space. Used to study several diseases, including artery disease (multiple); cerebrovascular disease (multiple); diabetes mellitus (multiple); end stage renal disease; and renal fibrosis. Biomarker of several diseases, including acute necrotizing pancreatitis; glomerulosclerosis (multiple); lung disease (multiple); middle cerebral artery infarction; and muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpine1 Products(1)

mRNA	Protein	Name
NM_012620.2	NP_036752.2	plasminogen activator inhibitor 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IDA IDA: Inferred from direct assay	9316343	RGD
enables serine-type endopeptidase inhibitor activity	IDA IDA: Inferred from direct assay	9316343	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to ATP	IEP IEP: Inferred from expression pattern	10712415	RGD
involved in cellular response to aldosterone	IEP IEP: Inferred from expression pattern	26617694	RGD
involved in cellular response to angiotensin	IEP IEP: Inferred from expression pattern	19051364	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9603932	RGD
involved in cellular response to cGMP	IEP IEP: Inferred from expression pattern	9812917	RGD
involved in cellular response to cycloheximide	IEP IEP: Inferred from expression pattern	9798919	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	1333984	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	10615432	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	9716558	RGD
involved in cellular response to glucagon stimulus	IEP IEP: Inferred from expression pattern	17721610	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	15828931	RGD
involved in cellular response to gravity	IEP IEP: Inferred from expression pattern	19574431	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	17474984	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	12409145	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	10590062	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	10590062	RGD
involved in cellular response to interleukin-1	IDA IDA: Inferred from direct assay	9420877	RGD
involved in cellular response to leukemia inhibitory factor	IEP IEP: Inferred from expression pattern	2170427	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20060032	RGD
involved in cellular response to low-density lipoprotein particle stimulus	IEP IEP: Inferred from expression pattern	11057874	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	20054150	RGD
involved in cellular response to metal ion	IEP IEP: Inferred from expression pattern	21596853	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	21596853	RGD
involved in cellular response to nicotine	IEP IEP: Inferred from expression pattern	21596853	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	15961275	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	10615432	RGD
involved in cellular response to potassium ion	IEP IEP: Inferred from expression pattern	21596853	RGD
involved in cellular response to resveratrol	IEP IEP: Inferred from expression pattern	25850408	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	19247458	RGD
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	23378038	RGD
involved in decidualization	IEP IEP: Inferred from expression pattern	8862764	RGD
involved in female gonad development	IDA IDA: Inferred from direct assay	8527517	RGD
involved in mast cell activation	IEP IEP: Inferred from expression pattern	15961275	RGD
involved in negative regulation of cell migration	IDA IDA: Inferred from direct assay	15596522	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	15596522	RGD
involved in negative regulation of endopeptidase activity	IDA IDA: Inferred from direct assay	10717410	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22659625	RGD
involved in positive regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	22659625	RGD
involved in positive regulation of coagulation	IMP IMP: Inferred from mutant phenotype	18239154	RGD
involved in positive regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15828931	RGD
involved in positive regulation of epithelium regeneration	IMP IMP: Inferred from mutant phenotype	17071586	RGD
involved in positive regulation of fibroblast proliferation	IMP IMP: Inferred from mutant phenotype	22659625	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	22659625	RGD
involved in positive regulation of keratinocyte migration	IMP IMP: Inferred from mutant phenotype	15174100	RGD
involved in positive regulation of receptor-mediated endocytosis	IMP IMP: Inferred from mutant phenotype	8626514	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	20083474	RGD
involved in response to epidermal growth factor	IEP IEP: Inferred from expression pattern	1333984	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	20838740	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	19099788	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	16500919	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9569197	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	26879937	RGD
involved in response to reactive oxygen species	IEP IEP: Inferred from expression pattern	12719791	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	17721610	RGD
involved in response to transforming growth factor beta	IEP IEP: Inferred from expression pattern	16105028	RGD
involved in tissue regeneration	IEP IEP: Inferred from expression pattern	12399226	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromaffin granule	IDA IDA: Inferred from direct assay	21596853	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	10717410	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	20083474	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Serpine1 Protein Structure

serpin

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

plasminogen activator inhibitor 1

PAI	PAI-1
endothelial plasminogen activator inhibitor	serine (or cysteine) peptidase inhibitor, clade E, member 1
serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	serine (or cysteine) proteinase inhibitor, clade E, member 1
serine (or cysteine) proteinase inhibitor, member 1	serpin E1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

Recombinant Serpine1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P73336	Serpin E1 Protein, Rat (HEK293, Fc)	P20961 (M1-P402)	≥95%
HY-P73655	Serpin E1 Protein, Rat (HEK293, His)	NP_036752.1 (S24-P402)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12720	SERPINE1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12721	Serpine1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12722	Serpine1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Serpine1	NCBI	NCBI:5054

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