2. Gene
  3. Pklr - pyruvate kinase L/R Gene

Pklr - pyruvate kinase L/R Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PK1; PKL; Pklg

Gene ID: 24651 | Gene type: protein coding

About Pklr

Summary

Enables Pyruvate Kinase activity. Involved in several processes, including cellular response to organonitrogen compound; pyruvate metabolic process; and response to purine-containing compound. Located in cytosol. Biomarker of hyperglycemia. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; Pyruvate Kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (Pyruvate Kinase L/R). [provided by Alliance of Genome Resources, Apr 2022]

Pklr Products(1)

mRNA Protein Name
NM_012624.3 NP_036756.3 pyruvate kinase PKLR
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables monosaccharide binding IPI
IPI: Inferred from physical interaction
6742850 RGD
enables pyruvate kinase activity IDA
IDA: Inferred from direct assay
1834654 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to epinephrine stimulus IEP
IEP: Inferred from expression pattern
10620345 RGD
involved in cellular response to insulin stimulus IDA
IDA: Inferred from direct assay
9395079 RGD
involved in glycolytic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in pyruvate biosynthetic process IDA
IDA: Inferred from direct assay
4273555 RGD
involved in response to ATP IDA
IDA: Inferred from direct assay
11104754 RGD
involved in response to cAMP IDA
IDA: Inferred from direct assay
9395079 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
16644726 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
11356723 RGD
involved in response to metal ion IEP
IEP: Inferred from expression pattern
11357483 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
11368649 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pyruvate kinase PKLR

L-PK

pyruvate kinase isozymes L/R

pyruvate kinase isozymes R/L

pyruvate kinase, liver and RBC

pyruvate kinase, liver and red blood cell

Recombinant Pklr Proteins

Cat. No. Product Name Accession Purity
HY-P700578 PKLR Protein, Rat (P. pastoris, His) P12928 (M1-S574) ≥95%

Related Agents

Approval
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12689 Mitapivat Activator 99.83% Yes
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122682 SBI-993 98.67% Unkown
HY-135884 Tebapivat Activator 99.66% Unkown
HY-12689B Mitapivat hemisulfate Activator / Unkown
HY-RS10601 PKLR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-12689A Mitapivat hemisulfate sesquihydrate Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pklr NCBI NCBI:5313