Scn2a - sodium voltage-gated channel alpha subunit 2 Gene

Rattus norvegicus

Also known as SCN; ScpII; NachII; Nav1.2; Scn2a1; Scn2a2; RII/RIIA; RNSCPIIR

Gene ID: 24766 | Gene type: protein coding

About Scn2a

Primary_assembly 3: 50,302,877-50,437,214 forward strand.mRatBN7.2:CM026976.1

This gene has 5 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 41 phenotypes. Restricted expression toward (RPKM 552.3).

Summary

Voltage-gated sodium channels are Transmembrane Glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the Sodium Channel alpha subunit gene family. In humans, variants of this gene are associated with seizure disorders and autism spectrum disorder. Mice homozygous for a knockout mutation die with severe hypoxia and extensive neuronal cell death, while gain of function mutations result in progressive seizure disorder. [provided by RefSeq, Nov 2016]

Scn2a Products(1)

mRNA	Protein	Name
NM_012647.2	NP_036779.2	sodium channel protein type 2 subunit alpha

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables leucine zipper domain binding	IPI IPI: Inferred from physical interaction	17360357	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	10737807	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IDA IDA: Inferred from direct assay	25615535	RGD
enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential	IMP IMP: Inferred from mutant phenotype	25615535	RGD
enables voltage-gated sodium channel activity	IDA IDA: Inferred from direct assay	2442385	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	28029095	RGD
involved in cerebral cortex development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in corpus callosum development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in myelination	IEP IEP: Inferred from expression pattern	16652168	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	15917456	RGD
involved in optic nerve development	IEP IEP: Inferred from expression pattern	22473424	RGD
involved in sodium ion transmembrane transport	IDA IDA: Inferred from direct assay	28029095	RGD
involved in sodium ion transport	IDA IDA: Inferred from direct assay	2442385	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	22473424	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	12036953	RGD
located in node of Ranvier	IDA IDA: Inferred from direct assay	16652168	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	24297919	RGD
part of voltage-gated sodium channel complex	IDA IDA: Inferred from direct assay	2442385	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Scn2a Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

Na_channel_gate

Ion_trans

0
400
800
1200
1600
2005 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 2 subunit alpha

RIIA sodium channel protein	sodium channel protein type II subunit alpha
sodium channel protein, brain II subunit alpha	sodium channel voltage-gated type II alpha polypeptide
sodium channel, voltage-gated, type 2, alpha 1 polypeptide	sodium channel, voltage-gated, type 2, alpha 1 subunit
sodium channel, voltage-gated, type II, alpha 1	sodium channel, voltage-gated, type II, alpha subunit
voltage-gated sodium channel subunit alpha Nav1.2

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150514	ARN1468	Inhibitor	99.34%	Unkown
HY-W081348	1-(4-Methoxyphenyl)-3-methyl-1H-pyrazol-5(4H)-one	Inhibitor	99.54%	Unkown
HY-107662	TCS PrP Inhibitor 13	Inducer	99.72%	Unkown
HY-RS12529	SCN2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12530	Scn2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12531	Scn2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scn2a	NCBI	NCBI:6326

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