Slc9a1 - solute carrier family 9 member A1 Gene

Rattus norvegicus

Also known as Nhe1

Gene ID: 24782 | Gene type: protein coding

About Slc9a1

Summary

Enables sodium:proton antiporter activity. Involved in several processes, including cellular response to electrical stimulus; positive regulation of mitochondrial membrane permeability; and regulation of apoptotic process. Located in several cellular components, including T-tubule; basolateral plasma membrane; and intercalated disc. Used to study cataract; middle cerebral artery infarction; and proteinuria. Biomarker of hyperthyroidism; hypothyroidism; renovascular hypertension; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 19 and congestive heart failure. Orthologous to human SLC9A1 (solute carrier family 9 member A1). [provided by Alliance of Genome Resources, Apr 2022]

Slc9a1 Products(1)

mRNA	Protein	Name
NM_012652.2	NP_036784.1	sodium/hydrogen exchanger 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12576672	RGD
enables sodium:proton antiporter activity	IDA IDA: Inferred from direct assay	18321853	RGD
enables sodium:proton antiporter activity	IMP IMP: Inferred from mutant phenotype	16002403	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cardiac muscle cell contraction	IEP IEP: Inferred from expression pattern	20868366	RGD
involved in cell differentiation	IEP IEP: Inferred from expression pattern	16495213	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	20868366	RGD
involved in cellular response to cold	IEP IEP: Inferred from expression pattern	15452191	RGD
involved in cellular response to electrical stimulus	IEP IEP: Inferred from expression pattern	20868366	RGD
involved in cellular response to hypoxia	IDA IDA: Inferred from direct assay	20868366	RGD
involved in cellular response to insulin stimulus	IDA IDA: Inferred from direct assay	20868366	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20868366	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17552965	RGD
involved in positive regulation of action potential	IMP IMP: Inferred from mutant phenotype	18319243	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	22407349	RGD
involved in positive regulation of cell growth	IMP IMP: Inferred from mutant phenotype	19687166	RGD
involved in positive regulation of intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	14600156	RGD
involved in positive regulation of mitochondrial membrane permeability	IMP IMP: Inferred from mutant phenotype	21297023	RGD
involved in regulation of intracellular pH	IMP IMP: Inferred from mutant phenotype	22387884	RGD
involved in regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	21659487	RGD
involved in response to acidic pH	IDA IDA: Inferred from direct assay	18321853	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	17308111	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	20868366	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	23869188	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	9438178	RGD
located in cell surface	IDA IDA: Inferred from direct assay	20868366	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	20868366	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20868366	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	18321853	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	20868366	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sodium/hydrogen exchanger 1

NHE-1	Na(+)/H(+) exchanger 1
Solute carrier family 9 (sodium/hydrogen exchanger 1), antiporter, Na+/H+, (amiloride sensitive)	solute carrier family 9 (sodium/hydrogen exchanger), member 1
solute carrier family 9 member 1	solute carrier family 9, subf

Slc9a1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Slc9a1	P26431	Chp2	Rattus norvegicus	Q810D1	Pull Down	12576672

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13341	SLC9A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS13349	SLC9B1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc9a1	NCBI	NCBI:6548

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