ALPI - alkaline phosphatase, intestinal Gene

Homo sapiens

Also known as IAP

Gene ID: 248 | Gene type: protein coding

About ALPI

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:232,456,153-232,460,753 (from NCBI)

This gene has 2 transcripts (splice variants), 362 orthologues and 3 paralogues. Biased expression in duodenum (RPKM 85.5), small intestine (RPKM 83.4) and 1 other tissue.

Summary

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The intestinal Alkaline Phosphatase gene encodes a digestive brush-border Enzyme. This Enzyme is a component of the gut mucosal defense system and is thought to function in the detoxification of lipopolysaccharide, and in the prevention of Bacterial translocation in the gut. [provided by RefSeq, Dec 2014]

ALPI Products(1)

mRNA	Protein	Name
NM_001631.5	NP_001622.2	intestinal-type alkaline phosphatase precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protease binding	IPI IPI: Inferred from physical interaction	18307834	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALPI Protein Structure

Alk_phosphatase

0
100
200
300
400
500
528 a.a.

Protein Preferred Names

Protein Names

intestinal-type alkaline phosphatase

Kasahara isozyme

Recombinant ALPI Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71692	ALPI Protein, Human (His)	P09923 (26E-500C)	≥95%
HY-P72822	ALPI Protein, Human (HEK293, His)	P09923 (V20-D503)	≥95%
HY-P72821	ALPI Protein, Human (HEK293, Fc)	P09923 (M1-D503)	≥95%
HY-P700394	ALPI Protein, Human (HEK293, N-His)	P09923 (V20-D503)	≥95%

Related Diseases

Diseases

Alias

Hypophosphatasia

Phosphoethanolaminuria	Childhood Hypophosphatasia
Deficiency Of Alkaline Phosphatase	Hypophospatasia, Childhood
Hypophosphatasia Mild	Phosphoethanol-Aminuria
Rathburn Disease	Hpp
Rathbun Disease	Hypophosphatasia, Childhood
Infantile Hypophosphatasia

Trachea Adenoid Cystic Carcinoma

Tracheal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma Of Trachea

Tracheal Cancer

Tracheal Carcinoma	Malignant Neoplasm Of Trachea
Tracheal Neoplasms	Pancoast Tumor
Pulmonary Sulcus Neoplasm	Pancoast Syndrome

Trachea Carcinoma

Pancoast Tumor	Carcinoma Of The Trachea
Pancoast'S Tumor	Malignant Superior Sulcus Tumor
Malignant Superior Sulcus Tumour	Pancoast Tumour
Pancoast'S Syndrome	Pancoast'S Tumour
Pulmonary Sulcus Tumor	Pulmonary Sulcus Tumour
Superior Pulmonary Sulcus Syndrome	Pancoast Syndrome

Testis Seminoma

Seminoma Of Testis	Seminoma Testis
Testicular Seminoma Pure	Seminoma

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00628	ALPI Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ALPI	RGD	RGD:2099
Macaca mulatta	ALPI	VGNC	VGNC:69800
Mus musculus	ALPI	NCBI	NCBI:76768
Others	ALPI	NCBI

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