1. Gene
  2. FRZB - frizzled related protein Gene

FRZB - frizzled related protein Gene

Homo sapiens

Also known as FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN

Gene ID: 2487 | Gene type: protein coding

About FRZB

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,833,275-182,866,637 (from NCBI)

This gene has 1 transcript (splice variant), 294 orthologues, 15 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 48.5), gall bladder (RPKM 25.9) and 20 other tissues.

Summary

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

FRZB Products(1)

mRNA Protein Name
NM_001463.4 NP_001454.2 secreted frizzled-related protein 3 precursor

FRZB Protein Structure

Fz

Fz: Fz domain (35 - 148)

NTR

NTR: UNC-6/NTR/C345C module (193 - 289)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 3

frezzled

Recombinant FRZB Proteins

Cat. No. Product Name Accession Purity
HY-P75780 FRZB Protein, Human (HEK293, His) Q92765/NP_001454.2 (A32-N325) ≥95%

Related Diseases

Diseases Alias
Osteoarthritis

Osteoarthrosis

Degenerative Joint Disease

Hypertrophic Arthritis

Arthropathy

Degenerative Polyarthritis

Degenerative Arthritis

Osteoarthrosis And Allied Disorder

Arthritis, Degenerative

Oa

Osteoarthritis Deformans

Osteoarthrosis Deformans

Kashin-Beck Disease

Holzgreve Syndrome

Holzgreve-Wagner-Rehder Syndrome

Holzgreve Wagner Rehder Syndrome

Complex Congenital Heart Defect, Renal Agenesis And Cleft Lip And Palate

Cleft Palate-Potter Sequence-Congenital Heart Anomalies-Mesoaxial Polydactyly-Multiple Malformations Syndrome

Monofixation Syndrome
Retinal Degeneration

Degeneration Of Retina

Localized Osteosarcoma

Localised Osteogenic Sarcoma

Localised Osteosarcoma

Localized Osteogenic Sarcoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Sclerosteosis

Cortical Hyperostosis With Syndactyly

Sost

Cortical Hyperostosis-Syndactyly Syndrome

Van Buchem Disease

Hyperostosis Corticalis Generalisata

Hyperphosphatasemia Tarda

VBCH

Sost-Related Sclerosing Bone Dysplasia

Endosteal Hyperostosis Autosomal Recessive

Sclerosteosis

Endosteal Hyperostosis, Autosomal Recessive

Hyperotosis Corticalis Generalisata Familiaris

Sost Sclerosing Bone Dysplasia

Smith-Lemli-Opitz Syndrome

Osteoporosis

Postmenopausal Osteoporosis

Osteoporosis, Postmenopausal

Bone Mineral Density Quantitative Trait Locus

Bmnd

Osteoporosis, Involutional

Osteoporosis, Susceptibility To

Osteoporosis, Postmenopausal, Susceptibility

Bone Mineral Density Variation Qtl, Osteoporosis

OSTEOP

Involutional Osteoporosis

Senile Osteoporosis

Osteoporosis Postmenopausal

Bone Mineral Density, Quantitative Trait Locus

Osteoporosis, Senile

Idiopathic Osteoporosis

Bone Rarefaction Nos

Type 1 Osteoporosis

Nanophthalmos

Nanophthalmia

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus FRZB VGNC VGNC:62372
Rattus norvegicus FRZB RGD RGD:1311315
Mus musculus FRZB MGD MGI:892032
Bos taurus FRZB VGNC VGNC:29124
Macaca mulatta FRZB VGNC VGNC:72819
Canis familiaris FRZB VGNC VGNC:53094
Others FRZB NCBI