Stx1b - syntaxin 1B Gene

Rattus norvegicus

Also known as Stx2; Stx1b2

Gene ID: 24923 | Gene type: protein coding

About Stx1b

Summary

Enables protein domain specific binding activity and signaling receptor binding activity. Involved in exocytic insertion of neurotransmitter receptor to postsynaptic membrane and regulation of exocytosis. Located in presynaptic active zone membrane. Human ortholog(s) of this gene implicated in generalized epilepsy with febrile seizures plus 9. Orthologous to human STX1B (syntaxin 1B). [provided by Alliance of Genome Resources, Apr 2022]

Stx1b Products(1)

mRNA	Protein	Name
NM_012700.2	NP_036832.1	syntaxin-1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12093152	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	8999968	RGD
enables signaling receptor binding	IPI IPI: Inferred from physical interaction	21424589	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in protein localization to membrane	IDA IDA: Inferred from direct assay	12093152	RGD
involved in regulation of exocytosis	IMP IMP: Inferred from mutant phenotype	11245593	RGD
involved in vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	11245593	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in presynaptic membrane	IDA IDA: Inferred from direct assay	12093152	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

syntaxin-1B

P35B	Syntaxin 2
syntaxin 1B2

Stx1b Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Stx1b	P61265	Rnf40	Rattus norvegicus	Q8CJB9	Y2H	12121982

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13981	STX1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Stx1b	NCBI	NCBI:112755

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