Rnf40 - ring finger protein 40 Gene

Rattus norvegicus

Gene ID: 266712 | Gene type: protein coding

About Rnf40

Summary

Enables syntaxin-1 binding activity; ubiquitin conjugating Enzyme binding activity; and ubiquitin-protein transferase activity. Involved in positive regulation of cellular protein metabolic process; response to peptide hormone; and ubiquitin-dependent protein catabolic process. Located in axon terminus and cytosol. Is extrinsic component of membrane. Part of protein-containing complex. Biomarker of nephrogenic diabetes insipidus. Orthologous to human RNF40 (ring finger protein 40). [provided by Alliance of Genome Resources, Apr 2022]

Rnf40 Products(1)

mRNA	Protein	Name
NM_153471.1	NP_703201.1	E3 ubiquitin-protein ligase BRE1B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12121982	RGD
enables syntaxin-1 binding	IPI IPI: Inferred from physical interaction	12121982	RGD
enables ubiquitin conjugating enzyme binding	IDA IDA: Inferred from direct assay	12121982	RGD
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	12121982	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of proteasomal protein catabolic process	IDA IDA: Inferred from direct assay	12121982	RGD
involved in positive regulation of protein polyubiquitination	IDA IDA: Inferred from direct assay	12121982	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	21734099	RGD
involved in ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	12121982	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	12121982	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase BRE1B

BRE1-B	RING-type E3 ubiquitin transferase BRE1B
protein staring	ring finger protein 40, E3 ubiquitin protein ligase
staring protein	syntaxin-1-interacting RING finger protein

Rnf40 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Rnf40	Q8CJB9	UBE2L6	Homo sapiens	O14933	Anti Tag CoIP	12121982
Intra	Rnf40	Q8CJB9	Stx1b	Rattus norvegicus	P61265	Anti Tag CoIP	12121982

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12091	RNF40 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rnf40	NCBI	NCBI:9810

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