Adrb1 - adrenoceptor beta 1 Gene

Rattus norvegicus

Also known as B1AR; RATB1AR

Gene ID: 24925 | Gene type: protein coding

About Adrb1

Summary

Enables amine binding activity and beta1-adrenergic receptor activity. Involved in several processes, including positive regulation of transport; regulation of heart contraction; and regulation of muscle system process. Located in cytoplasm; nucleus; and plasma membrane. Used to study congestive heart failure; dilated cardiomyopathy; myocardial infarction; periodontitis; and renovascular hypertension. Biomarker of hyperglycemia; hypertension; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including chronic obstructive pulmonary disease; hypertension (multiple); low tension glaucoma; obstructive sleep apnea; and periodontitis. Orthologous to human ADRB1 (adrenoceptor beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Adrb1 Products(1)

mRNA	Protein	Name
NM_012701.2	NP_036833.2	beta-1 adrenergic receptor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine binding	IPI IPI: Inferred from physical interaction	6289140	RGD
enables beta1-adrenergic receptor activity	IDA IDA: Inferred from direct assay	12514203	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16316992	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12514203	RGD
involved in Rho protein signal transduction	IMP IMP: Inferred from mutant phenotype	18306009	RGD
involved in glycogen catabolic process	IDA IDA: Inferred from direct assay	17911346	RGD
involved in inhibitory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	18262504	RGD
involved in lipid homeostasis	IMP IMP: Inferred from mutant phenotype	22457517	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	17961922	RGD
involved in negative regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	18306009	RGD
involved in negative regulation of urine volume	IDA IDA: Inferred from direct assay	7912752	RGD
involved in positive regulation of adenylate cyclase activity	IMP IMP: Inferred from mutant phenotype	21143600	RGD
involved in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	18202135	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17143192	RGD
involved in positive regulation of calcium ion import across plasma membrane	IDA IDA: Inferred from direct assay	11408541	RGD
involved in positive regulation of cation channel activity	IDA IDA: Inferred from direct assay	22505670	RGD
involved in positive regulation of cell growth involved in cardiac muscle cell development	IMP IMP: Inferred from mutant phenotype	18194989	RGD
involved in positive regulation of heart rate	IMP IMP: Inferred from mutant phenotype	9089896	RGD
involved in positive regulation of long-term synaptic potentiation	IDA IDA: Inferred from direct assay	21848869	RGD
involved in positive regulation of systemic arterial blood pressure	IMP IMP: Inferred from mutant phenotype	18931026	RGD
involved in positive regulation of the force of heart contraction by norepinephrine	IDA IDA: Inferred from direct assay	19133992	RGD
involved in protein localization to organelle	IDA IDA: Inferred from direct assay	22105697	RGD
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	19133992	RGD
involved in regulation of cardiac muscle cell contraction	IDA IDA: Inferred from direct assay	19525381	RGD
involved in regulation of cardiac muscle cell contraction	IMP IMP: Inferred from mutant phenotype	22216755	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	12391161	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-1 adrenergic receptor

adrenergic receptor, beta 1	adrenergic, beta-1-, receptor
beta 1-adrenergic receptor beta 1-AR	beta-1 adrenoceptor
beta-1 adrenoreceptor

Adrb1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Adrb1	P18090	Magi3	Rattus norvegicus	Q9JK71	Anti Bait CoIP	16316992

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00414	ADRB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adrb1	NCBI	NCBI:153

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