2. Gene
  3. CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cyp19; Cyp19a; p450arom; Aromatase

Gene ID: 25147 | Gene type: protein coding

About CYP19A1

Primary_assembly 8: 54,553,165-54,580,758 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 319 orthologues, 17 paralogues and is associated with 48 phenotypes. Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues.

Summary

Enables aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP19A1 Products(1)

mRNA Protein Name
NM_017085.3 NP_058781.2 aromatase

CYP19A1 Protein Structure

CYP19A1

CYP19A1: cd20616 (71 - 484)

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  • 503 a.a.
Protein Preferred Names Protein Names

aromatase

CYPXIX

Cytochrome P450, 19, aromatase

P-450AROM

cytochrome P-450AROM

cytochrome P450 19A1

cytochrome P450 19A1-like

cytochrome P450 family 19 subfamily a

cytochrome P450, subfamily 19

estrogen synthase

estrogen synthetase

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-150775 Nonsteroidal aromatase inhibitor 1 Inhibitor 98.88% Unkown
HY-155493 CYP19A1/CYP11B2-IN-1 99.85% Unkown
HY-RS03438 CYP19A1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03439 Cyp19a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03440 CYP19A1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYP19A1 NCBI NCBI:1588