CYP19A1 - cytochrome P450, family 19, subfamily a, polypeptide 1 Gene

Rattus norvegicus

Also known as Cyp19; Cyp19a; p450arom; Aromatase

Gene ID: 25147 | Gene type: protein coding

About CYP19A1

Primary_assembly 8: 54,553,165-54,580,758 reverse strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 319 orthologues, 17 paralogues and is associated with 48 phenotypes. Biased expression in Brain (RPKM 2.6), Uterus (RPKM 2.1) and 7 other tissues.

Summary

Enables aromatase activity. Involved in several processes, including animal organ development; carboxylic acid metabolic process; and cellular hormone metabolic process. Located in several cellular components, including dendritic spine; neuronal cell body; and synaptic vesicle. Used to study endometriosis and polycystic ovary syndrome. Biomarker of hypertension; hypothyroidism; placental insufficiency; polycystic ovary syndrome; and protein-energy malnutrition. Human ortholog(s) of this gene implicated in several diseases, including aromatase excess syndrome; bladder neck obstruction; esophagus adenocarcinoma; ovarian disease (multiple); and prostate disease (multiple). Orthologous to human CYP19A1 (Cytochrome P450 family 19 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

CYP19A1 Products(1)

mRNA	Protein	Name
NM_017085.3	NP_058781.2	aromatase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aromatase activity	IDA IDA: Inferred from direct assay	16269516	RGD
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen	IDA IDA: Inferred from direct assay	11850226	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in C21-steroid hormone metabolic process	IDA IDA: Inferred from direct assay	19190754	RGD
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	8097866	RGD
involved in androgen metabolic process	IMP IMP: Inferred from mutant phenotype	19492405	RGD
involved in bile acid metabolic process	IEP IEP: Inferred from expression pattern	20026603	RGD
involved in biphenyl metabolic process	IEP IEP: Inferred from expression pattern	19464308	RGD
involved in bone development	IEP IEP: Inferred from expression pattern	15012600	RGD
involved in calcineurin-mediated signaling	IMP IMP: Inferred from mutant phenotype	25057110	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	20434519	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	20810564	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	18353182	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	16569475	RGD
involved in cellular response to hydrostatic pressure	IEP IEP: Inferred from expression pattern	21047944	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	20059580	RGD
involved in estrogen biosynthetic process	IDA IDA: Inferred from direct assay	19665544	RGD
involved in granulocyte differentiation	IEP IEP: Inferred from expression pattern	18401763	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	21047951	RGD
involved in hypothalamus development	IEP IEP: Inferred from expression pattern	15804399	RGD
involved in luteinization	IEP IEP: Inferred from expression pattern	23183184	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	20554652	RGD
involved in melatonin metabolic process	IEP IEP: Inferred from expression pattern	17700567	RGD
involved in negative regulation of bone resorption	IMP IMP: Inferred from mutant phenotype	8694895	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	20920559	RGD
involved in regulation of synapse structure or activity	IMP IMP: Inferred from mutant phenotype	17005180	RGD
involved in response to cesium ion	IEP IEP: Inferred from expression pattern	20451883	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	21115103	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	19734697	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	21126571	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	18821396	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	20708649	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20821433	RGD
involved in response to testosterone	IEP IEP: Inferred from expression pattern	16569475	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19497980	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon terminus	IDA IDA: Inferred from direct assay	14694190	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	14694190	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19565659	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	14694190	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	20926671	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CYP19A1 Protein Structure

CYP19A1

0
100
200
300
400
503 a.a.

Protein Preferred Names

Protein Names

aromatase

CYPXIX	Cytochrome P450, 19, aromatase
P-450AROM	cytochrome P-450AROM
cytochrome P450 19A1	cytochrome P450 19A1-like
cytochrome P450 family 19 subfamily a	cytochrome P450, subfamily 19
estrogen synthase	estrogen synthetase

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150775	Nonsteroidal aromatase inhibitor 1	Inhibitor	98.88%	Unkown
HY-155493	CYP19A1/CYP11B2-IN-1	Inhibitor	99.85%	Unkown
HY-RS03438	CYP19A1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03439	Cyp19a1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03440	CYP19A1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-Z4488	5-Dibromomethyl anastrozole	Control	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	CYP19A1	NCBI	NCBI:1588

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