CYP19A1/CYP11B2-IN-1

Cat. No.: HY-155493 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

CYP19A1/CYP11B2-IN-1 (Compound X21) is a potent and selective aromatase and aldosterone synthase dual inhibitor with IC₅₀s of 2.3 nM and 29 nM for aromatase (CYP19A1) and aldosterone synthase (CYP11B2), respectively. CYP19A1/CYP11B2-IN-1 has excellent antiproliferative and pro-apoptotic activity against the cancer cell. CYP19A1/CYP11B2-IN-1 can be used for research of breast cancer.

For research use only. We do not sell to patients.

CYP19A1/CYP11B2-IN-1 Chemical Structure

CAS No. : 183500-36-9

Size	Price	Stock	Quantity
5 mg	USD 220	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 350	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 700	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 1150	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1850	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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•Related Screening Libraries:

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View All Cytochrome P450 Isoform Specific Products:

View All Isoforms

CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

CYP19A1/CYP11B2-IN-1 (Compound X21) (0.001-100 μM, 24 h) shows a time- and concentration-dependent proliferation inhibition on MCF-7 and MDA-MB-231 cells^[1].
CYP19A1/CYP11B2-IN-1 (700 nM, 24 h) significantly inhibits the phosphorylation of mTOR in MCF-7 cells, thereby negatively modulating the PI3K/Akt/mTOR axis^[1].
CYP19A1/CYP11B2-IN-1 (20-30 μM) has no significant inhibition of hERG and Nav1.5, indicating no toxicity to the heart^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	MCF-7 and MDA-MB-231 cells
Concentration:	0.001-100 μM
Incubation Time:	24-72 h
Result:	Inhibited the MCF-7 cells proliferation with an IC₅₀ of 0.26±0.03 μM. Inhibited the MDA-MB-231 cells proliferation with an IC₅₀ of 27.10 ± 5.15 μM. Confirmed no toxicity on normal cells.

Apoptosis Analysis^[1]

Cell Line:	MCF-7 and MDA-MB-231 cells
Concentration:	0.35-1 μM, 10-50 μM
Incubation Time:	24 h
Result:	Increase in the extent of DNA fragmentation. Increased the apoptotic signal in MDA-MB-231 cells with higher concentrations (> 40 μM).

Molecular Weight

213.24

Formula

C₁₂H₁₁N₃O

CAS No.

183500-36-9

Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CC=C(CN2C=NC=C2CO)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (586.19 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6896 mL	23.4478 mL	46.8955 mL
5 mM	0.9379 mL	4.6896 mL	9.3791 mL
10 mM	0.4690 mL	2.3448 mL	4.6896 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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Concentration _(final)

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (272 KB) SDS (251 KB)

COA (248 KB) HNMR (238 KB) LCMS (84 KB)

Handling Instructions (2659 KB)

References

[1]. Tinivella A, et al. Discovery of a Potent Dual Inhibitor of Aromatase and Aldosterone Synthase. ACS Pharmacology & Translational Science. 2023 Nov 23.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.6896 mL	23.4478 mL	46.8955 mL	117.2388 mL
	5 mM	0.9379 mL	4.6896 mL	9.3791 mL	23.4478 mL
	10 mM	0.4690 mL	2.3448 mL	4.6896 mL	11.7239 mL
	15 mM	0.3126 mL	1.5632 mL	3.1264 mL	7.8159 mL
	20 mM	0.2345 mL	1.1724 mL	2.3448 mL	5.8619 mL
	25 mM	0.1876 mL	0.9379 mL	1.8758 mL	4.6896 mL
	30 mM	0.1563 mL	0.7816 mL	1.5632 mL	3.9080 mL
	40 mM	0.1172 mL	0.5862 mL	1.1724 mL	2.9310 mL
	50 mM	0.0938 mL	0.4690 mL	0.9379 mL	2.3448 mL
	60 mM	0.0782 mL	0.3908 mL	0.7816 mL	1.9540 mL
	80 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4655 mL
	100 mM	0.0469 mL	0.2345 mL	0.4690 mL	1.1724 mL