Casp1 - caspase 1 Gene

Rattus norvegicus

Also known as Ice; p45; Il1bc

Gene ID: 25166 | Gene type: protein coding

About Casp1

Primary_assembly 8: 2,587,831-2,597,383 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 456 orthologues, 12 paralogues and is associated with 40 phenotypes. Biased expression in Spleen (RPKM 365.4), Lung (RPKM 223.6) and 8 other tissues.

Summary

Enables scaffold protein binding activity. Involved in several processes, including myoblast fusion; positive regulation of circadian sleep/wake cycle, non-REM sleep; and positive regulation of interleukin-1 beta production. Located in cytoplasm; neuron projection; and nucleus. Part of protein-containing complex. Used to study acute kidney failure and visual epilepsy. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 Products(1)

mRNA	Protein	Name
NM_012762.3	NP_036894.3	caspase-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18367607	RGD
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	19416975	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in lung development	IEP IEP: Inferred from expression pattern	12396474	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	16197515	RGD
involved in microglial cell activation	IMP IMP: Inferred from mutant phenotype	15149850	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	12396474	RGD
involved in myoblast fusion	IMP IMP: Inferred from mutant phenotype	12832042	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	15663890	RGD
involved in positive regulation of circadian sleep/wake cycle, non-REM sleep	IMP IMP: Inferred from mutant phenotype	16455762	RGD
involved in positive regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	17384935	RGD
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	16942597	RGD
involved in response to hypoxia	IDA IDA: Inferred from direct assay	12829320	RGD
involved in response to lipopolysaccharide	IMP IMP: Inferred from mutant phenotype	17384935	RGD
involved in response to organic cyclic compound	IDA IDA: Inferred from direct assay	17561093	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20638366	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	16165281	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of protein-containing complex	IDA IDA: Inferred from direct assay	19416975	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp1 Protein Structure

CARD_CASP1-like

CASc

0
100
200
300
402 a.a.

Protein Preferred Names

Protein Names

caspase-1

IL-1 beta-converting enzyme	Interleukin 1beta converting enzyme
interleukin 1, beta, convertase	interleukin-1 beta-converting enzyme

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150536	EP39	Inhibitor	/	Unkown
HY-RS01941	CASP1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01942	Casp1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01943	Casp1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp1	NCBI	NCBI:834

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