2. Apoptosis Epigenetics Cell Cycle/DNA Damage Immunology/Inflammation Metabolic Enzyme/Protease
  3. Caspase PARP Pyroptosis Interleukin Related Glutathione Peroxidase IFNAR
  4. IRF1-IN-2

IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury.

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IRF1-IN-2 Chemical Structure

IRF1-IN-2 Chemical Structure

CAS No. : 708245-32-3

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Based on 1 publication(s) in Google Scholar

IRF1-IN-2 Related Antibodies

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Description

IRF1-IN-2 (Compound I-19) is an IRF1 inhibitor. IRF1-IN-2 decreases the recruitment of IRF1 to the promoter of CASP1. IRF1-IN-2 inhibits cell death signaling pathway (i.e., cleavage of Caspase 1, GSDMD, IL-1 and PARP1; inhibits the Pho of TKB1, upregulates GPX4 and downregulates FACL4). IRF1-IN-2 has a protective effect on ionizing radiation-induced inflammatory skin injury[1].

IC50 & Target[1]

PARP-1

 

IL-1

 

Caspase-1

 

In Vitro

IRF1-IN-2 pretreatment (20 μM, 12 h) decreases the recruitment of IRF1 to the promoter of CASP1 in irradiated HaCaT cells (20 Gy)[1].
IRF1-IN-2 (20 μM, 24 h) attenuates the NSP-10 plasmid transfection-induced IRF1 activation in HELF and WS1 cells[1].
IRF1-IN-2 protects A375 cells against radiation (20 Gy)[1].
IRF1-IN-2 inhibits cell death signaling pathways, including inhibition of cleavage for Caspase 1, GSDMD, IL-1 and PARP1, phosphorylation of TKB1, up-regulation of GPX4 and down-regulation of FACL4[1].
IRF1-IN-2 maintains mitochondrial activity and ROS production in skin cells in the early stage after irradiation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

IRF1-IN-2 Related Antibodies
In Vivo

IRF1-IN-2 pretreatment (100 μg/d, s.c., one every other day before irradiation) has a potential protective effect in 35 Gy radiation-induced inflammatory skin injury mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Radiogenic skin injury mice (intraperitoneal injection of pentobarbital sodium (1%, 30 mg/kg), 35 Gy at the dose rate of 1000 cGy/min by a 6-MeV electron beam)[1]
Dosage: 100 μg/d
Administration: Subcutaneous injection (s.c.), one every other day before irradiation, pretreatment
Result: Showed a significant reduction in acute skin inflammatory manifestations, such as erythema and exudation.
Showed protective effects on the function and structural integrity of radiation-induced lesions to the claws.
Molecular Weight

360.43

Formula

C18H20N2O4S
CAS No.
Appearance

Solid

SMILES

O=C(NC1=CC=C(S(=O)(N2CCCC2)=O)C=C1)C3=CC=CC=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (346.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7745 mL 13.8723 mL 27.7446 mL
5 mM 0.5549 mL 2.7745 mL 5.5489 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.7745 mL 13.8723 mL 27.7446 mL 69.3616 mL
5 mM 0.5549 mL 2.7745 mL 5.5489 mL 13.8723 mL
10 mM 0.2774 mL 1.3872 mL 2.7745 mL 6.9362 mL
15 mM 0.1850 mL 0.9248 mL 1.8496 mL 4.6241 mL
20 mM 0.1387 mL 0.6936 mL 1.3872 mL 3.4681 mL
25 mM 0.1110 mL 0.5549 mL 1.1098 mL 2.7745 mL
30 mM 0.0925 mL 0.4624 mL 0.9248 mL 2.3121 mL
40 mM 0.0694 mL 0.3468 mL 0.6936 mL 1.7340 mL
50 mM 0.0555 mL 0.2774 mL 0.5549 mL 1.3872 mL
60 mM 0.0462 mL 0.2312 mL 0.4624 mL 1.1560 mL
80 mM 0.0347 mL 0.1734 mL 0.3468 mL 0.8670 mL
100 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6936 mL
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IRF1-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

IRF1-IN-2708245-32-3CaspasePARPPyroptosisInterleukin RelatedGlutathione PeroxidaseIFNARpoly ADP ribose polymerase ILInterferon-α/β receptorInterferon-alpha/beta receptorRadiationHELFHaCaTWS1Skin injuryErythemaNSP-10Inhibitorinhibitorinhibit

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