1. Gene
  2. PDGFRA - platelet derived growth factor receptor alpha Gene

PDGFRA - platelet derived growth factor receptor alpha Gene

Rattus norvegicus

Also known as APDGFR; PDGFACE

Gene ID: 25267 | Gene type: protein coding

About PDGFRA

Primary_assembly 14: 33,005,839-33,054,335 reverse strand.mRatBN7.2:CM026987.1

This gene has 2 transcripts (splice variants), 204 orthologues, 54 paralogues and is associated with 53 phenotypes. Biased expression in Uterus (RPKM 247.4), Kidney (RPKM 24.5) and 9 other tissues.

Summary

Enables phosphatidylinositol 3-kinase binding activity and platelet-derived growth factor alpha-receptor activity. Involved in several processes, including animal organ development; cellular response to interleukin-1; and positive regulation of branching involved in lung morphogenesis. Located in several cellular components, including axon; nucleus; and plasma membrane. Used to study middle cerebral artery infarction. Biomarker of chronic ulcer of skin; hypertension; oligohydramnios; pulmonary fibrosis; and sciatic neuropathy. Human ortholog(s) of this gene implicated in hematologic Cancer (multiple); hypereosinophilic syndrome; and pancreatic Cancer. Orthologous to human PDGFRA (platelet derived growth factor receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

PDGFRA Products(2)

mRNA Protein Name
NM_012802.1 NP_036934.1 platelet-derived growth factor receptor alpha precursor
NM_012802.1 NP_036934.1 platelet-derived growth factor receptor alpha precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables phosphatidylinositol 3-kinase binding IPI
IPI: Inferred from physical interaction
18421086 RGD
enables platelet-derived growth factor alpha-receptor activity IDA
IDA: Inferred from direct assay
2157969 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to fibroblast growth factor stimulus IEP
IEP: Inferred from expression pattern
14593115 RGD
involved in cellular response to interleukin-1 IEP
IEP: Inferred from expression pattern
7546776 RGD
involved in inner ear development IEP
IEP: Inferred from expression pattern
15267171 RGD
involved in lung growth IMP
IMP: Inferred from mutant phenotype
8879189 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
11870082 RGD
involved in positive regulation of branching involved in lung morphogenesis IMP
IMP: Inferred from mutant phenotype
8879189 RGD
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
15267171 RGD
involved in positive regulation of peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
2157969 RGD
involved in response to cytokine IEP
IEP: Inferred from expression pattern
15155567 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
14724432 RGD
involved in response to estrogen IEP
IEP: Inferred from expression pattern
14724432 RGD
involved in response to formaldehyde IEP
IEP: Inferred from expression pattern
18045764 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
15534218 RGD
involved in response to hyperoxia IEP
IEP: Inferred from expression pattern
15722379 RGD
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
19909480 RGD
located in cytoplasm IDA
IDA: Inferred from direct assay
11788434 RGD
located in nucleus IDA
IDA: Inferred from direct assay
11788434 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
11788434 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PDGFRA Protein Structure

Ig_3

Ig_3: pfam13927 (26 - 98)

Ig

Ig: cl11960 (210 - 308)

Ig

Ig: cd00096 (229 - 233)

Ig

Ig: cd00096 (242 - 246)

Ig

Ig: cd00096 (271 - 275)

Ig

Ig: cd00096 (285 - 290)

Ig

Ig: cd00096 (300 - 303)

Ig4_PDGFR

Ig4_PDGFR: cd05859 (311 - 411)

PTKc_PDGFR_alpha

PTKc_PDGFR_alpha: cd05105 (553 - 954)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1088 a.a.
Protein Preferred Names Protein Names

platelet-derived growth factor receptor alpha

CD140 antigen-like family member A

PDGF-R-alpha

PDGFR-alpha

alpha platelet-derived growth factor receptor

alpha-type platelet-derived growth factor receptor

platelet derived growth factor receptor, alpha polypeptide

platelet-derived growth factor alpha receptor

platelet-derived growth factor receptor alpha-like

Recombinant PDGFRA Proteins

Cat. No. Product Name Accession Purity
HY-P73721 PDGF R alpha Protein, Rat (HEK293, His) NP_036934.1 (L24-E523) ≥95%
HY-P73722 PDGF R alpha Protein, Rat (HEK293, Fc) G3V6A0 (L24-E523) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens PDGFRA NCBI NCBI:5156
Macaca fascicularis PDGFRA NCBI NCBI:102138392
Mus musculus PDGFRA NCBI NCBI:18595