2. Gene
  3. Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as CD140a; Pdgfr-2

Gene ID: 18595 | Gene type: protein coding

About Pdgfra

Chromosome 5: 75,312,953-75,358,876 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 99 phenotypes. Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 2.2) and 19 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]

Pdgfra Products(4)

mRNA Protein Name
NM_011058.3 NP_035188.2 platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347719.1 NP_001334648.1 platelet-derived growth factor receptor alpha isoform 2 precursor
NM_001083316.2 NP_001076785.1 platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347718.1 NP_001334647.1 platelet-derived growth factor receptor alpha isoform 2 precursor

Pdgfra Protein Structure

Ig_3

Ig_3: pfam13927 (27 - 99)

Ig

Ig: cl11960 (211 - 309)

Ig

Ig: cd00096 (230 - 234)

Ig

Ig: cd00096 (243 - 247)

Ig

Ig: cd00096 (272 - 276)

Ig

Ig: cd00096 (286 - 291)

Ig

Ig: cd00096 (301 - 304)

Ig4_PDGFR

Ig4_PDGFR: cd05859 (312 - 412)

PTKc_PDGFR_alpha

PTKc_PDGFR_alpha: cd05105 (554 - 955)

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  • 1089 a.a.
Protein Preferred Names Protein Names

platelet-derived growth factor receptor alpha

Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)

CD140 antigen-like family member A

PDGF alpha chain

PDGF-R-alpha

PDGFR-alpha

alpha-type platelet-derived growth factor receptor

Recombinant Pdgfra Proteins

Cat. No. Product Name Accession Purity
HY-P72496 PDGF R alpha Protein, Mouse (HEK293, His) P26618 (L25-E524) ≥95%
HY-P74645 PDGF R alpha Protein, Mouse (HEK293, Fc) NP_001334647.1 (L25-E524) ≥95%

Related Agents

Approval
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-101561 Avapritinib Inhibitor 99.94% Yes
HY-112306 Ripretinib 98.90% Yes
Pre-clinical Phase
Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108444 (Z)-FeCP-oxindole Inhibitor 99.62% Unkown
HY-108444A (E)-FeCP-oxindole Inhibitor / Unkown
HY-149510 MET/PDGFRA-IN-1 / Unkown
HY-149511 MET/PDGFRA-IN-2 / Unkown
HY-RS10254 PDGFRA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10255 Pdgfra Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS10256 PDGFRA Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfra NCBI NCBI:5156
Macaca fascicularis Pdgfra NCBI NCBI:102138392
Rattus norvegicus Pdgfra NCBI NCBI:25267