1. Gene
  2. Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

Pdgfra - platelet derived growth factor receptor, alpha polypeptide Gene

Mus musculus

Also known as CD140a; Pdgfr-2

Gene ID: 18595 | Gene type: protein coding

About Pdgfra

Chromosome 5: 75,312,953-75,358,876 forward strand.GRCm39:CM000998.3

This gene has 9 transcripts (splice variants), 204 orthologues, 53 paralogues and is associated with 99 phenotypes. Broad expression in limb E14.5 (RPKM 29.6), lung adult (RPKM 2.2) and 19 other tissues.

Summary

This gene encodes a member of the receptor tyrosine kinase family of proteins. Binding of platelet-derived growth factor protein ligands to this receptor triggers receptor dimerization and autophosphorylation, resulting in the activation of several downstream signaling pathways. Signaling through the encoded receptor plays a role in gastrulation and the development of nearly all organ systems. Mice lacking a functional copy of this gene reportedly exhibit defects in lung, skeleton, testis and the central nervous system, and die soon after birth. Alternative splicing and intronic polyadenylation of gene transcripts have been implicated in muscle regeneration and fibrosis in adult mice. [provided by RefSeq, Jan 2017]

Pdgfra Products(4)

mRNA Protein Name
NM_011058.3 NP_035188.2 platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347719.1 NP_001334648.1 platelet-derived growth factor receptor alpha isoform 2 precursor
NM_001083316.2 NP_001076785.1 platelet-derived growth factor receptor alpha isoform 1 precursor
NM_001347718.1 NP_001334647.1 platelet-derived growth factor receptor alpha isoform 2 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables platelet-derived growth factor alpha-receptor activity IDA
IDA: Inferred from direct assay
20110689 MGI
enables platelet-derived growth factor binding IDA
IDA: Inferred from direct assay
15372073 MGI
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
23160237 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within Leydig cell differentiation IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within adrenal gland development IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within anatomical structure morphogenesis IMP
IMP: Inferred from mutant phenotype
15543606 MGI
acts upstream of or within animal organ morphogenesis IMP
IMP: Inferred from mutant phenotype
10806482 MGI
involved in cardiac myofibril assembly IGI
IGI: Inferred from genetic interaction
11239463 MGI
involved in cell chemotaxis IMP
IMP: Inferred from mutant phenotype
20110689 MGI
involved in cell migration IMP
IMP: Inferred from mutant phenotype
20110689 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: Inferred from direct assay
20548288 MGI
involved in embryonic cranial skeleton morphogenesis IMP
IMP: Inferred from mutant phenotype
9226440 MGI
involved in embryonic digestive tract morphogenesis IMP
IMP: Inferred from mutant phenotype
10903171 MGI
acts upstream of or within estrogen metabolic process IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within extracellular matrix organization IMP
IMP: Inferred from mutant phenotype
15543606 MGI
acts upstream of or within face morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within female gonad development IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within hematopoietic progenitor cell differentiation IMP
IMP: Inferred from mutant phenotype
24029230 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
10331973 MGI
acts upstream of or within lung development IMP
IMP: Inferred from mutant phenotype
11803579 MGI
acts upstream of or within luteinization IGI
IGI: Inferred from genetic interaction
19056881 MGI
acts upstream of or within luteinization IMP
IMP: Inferred from mutant phenotype
19056881 MGI
acts upstream of or within male genitalia development IMP
IMP: Inferred from mutant phenotype
12651897 MGI
involved in metanephric glomerular capillary formation IGI
IGI: Inferred from genetic interaction
11239463 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
15543606 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: Inferred from direct assay
20110689 MGI
acts upstream of or within platelet-derived growth factor receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
17143286 MGI
involved in platelet-derived growth factor receptor-alpha signaling pathway IDA
IDA: Inferred from direct assay
20110689 MGI
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
20110689 MGI
involved in retina vasculature development in camera-type eye IGI
IGI: Inferred from genetic interaction
11239463 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within signal transduction involved in regulation of gene expression IDA
IDA: Inferred from direct assay
18462699 MGI
acts upstream of or within skeletal system morphogenesis IMP
IMP: Inferred from mutant phenotype
17143286 MGI
acts upstream of or within white fat cell differentiation IMP
IMP: Inferred from mutant phenotype
28049691 MGI
involved in wound healing IMP
IMP: Inferred from mutant phenotype
20110689 MGI
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
29237719 MGI
located in cell surface IDA
IDA: Inferred from direct assay
22265737 MGI
located in cilium IDA
IDA: Inferred from direct assay
29237719 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
22027834 MGI
located in external side of plasma membrane IDA
IDA: Inferred from direct assay
17350578 MGI
located in microvillus IDA
IDA: Inferred from direct assay
23266329 MGI
located in nucleus IDA
IDA: Inferred from direct assay
21146513 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pdgfra Protein Structure

Ig_3

Ig_3: pfam13927 (27 - 99)

Ig

Ig: cl11960 (211 - 309)

Ig

Ig: cd00096 (230 - 234)

Ig

Ig: cd00096 (243 - 247)

Ig

Ig: cd00096 (272 - 276)

Ig

Ig: cd00096 (286 - 291)

Ig

Ig: cd00096 (301 - 304)

Ig4_PDGFR

Ig4_PDGFR: cd05859 (312 - 412)

PTKc_PDGFR_alpha

PTKc_PDGFR_alpha: cd05105 (554 - 955)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1089 a.a.
Protein Preferred Names Protein Names

platelet-derived growth factor receptor alpha

Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha)

CD140 antigen-like family member A

PDGF alpha chain

PDGF-R-alpha

PDGFR-alpha

alpha-type platelet-derived growth factor receptor

Recombinant Pdgfra Proteins

Cat. No. Product Name Accession Purity
HY-P72496 PDGF R alpha Protein, Mouse (HEK293, His) P26618 (L25-E524) ≥95%
HY-P74645 PDGF R alpha Protein, Mouse (HEK293, Fc) NP_001334647.1 (L25-E524) ≥95%

Orthologs Information

Species Symbol Source ID
Homo sapiens Pdgfra NCBI NCBI:5156
Macaca fascicularis Pdgfra NCBI NCBI:102138392
Rattus norvegicus Pdgfra NCBI NCBI:25267