Cst3 - cystatin C Gene

Rattus norvegicus

Also known as CYSC

Gene ID: 25307 | Gene type: protein coding

About Cst3

Summary

Enables peptidase inhibitor activity and protease binding activity. Involved in several processes, including animal organ development; circadian sleep/wake cycle, REM sleep; and embryo implantation. Located in several cellular components, including multivesicular body; neuronal cell body; and nuclear membrane. Biomarker of intracranial aneurysm; iron deficiency anemia; and obesity. Human ortholog(s) of this gene implicated in CST3-related cerebral amyloid angiopathy and age related macular degeneration 11. Orthologous to several human genes including CST3 (Cystatin C). [provided by Alliance of Genome Resources, Apr 2022]

Cst3 Products(1)

mRNA	Protein	Name
NM_012837.1	NP_036969.1	cystatin-C precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables peptidase inhibitor activity	IDA IDA: Inferred from direct assay	8761177	RGD
enables protease binding	IDA IDA: Inferred from direct assay	2622871	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Sertoli cell development	IEP IEP: Inferred from expression pattern	9432134	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	17440810	RGD
involved in cellular response to oxidative stress	IEP IEP: Inferred from expression pattern	10930551	RGD
involved in cellular response to oxidative stress	IMP IMP: Inferred from mutant phenotype	16140167	RGD
involved in embryo implantation	IEP IEP: Inferred from expression pattern	16935259	RGD
involved in eye development	IEP IEP: Inferred from expression pattern	11431459	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	8286570	RGD
involved in positive regulation of DNA replication	IDA IDA: Inferred from direct assay	1540157	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	1540157	RGD
involved in response to axon injury	IEP IEP: Inferred from expression pattern	8738161	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	9222450	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16935259	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	8590041	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	18723004	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	2757396	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	16414118	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16248890	RGD
involved in salivary gland development	IEP IEP: Inferred from expression pattern	10075146	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	14738488	RGD
located in basement membrane	IDA IDA: Inferred from direct assay	15872057	RGD
located in cell projection	IDA IDA: Inferred from direct assay	16309830	RGD
located in contractile muscle fiber	IDA IDA: Inferred from direct assay	8245434	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	2689174	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	10950881	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	14738488	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	15872057	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	16414118	RGD
located in vesicle	IDA IDA: Inferred from direct assay	10950881	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cystatin-C

Cystatin C (cysteine proteinase inhibitor)

cystatin-3

Recombinant Cst3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74209	Cystatin C/CST3 Protein, Rat (HEK293, His)	P14841 (M1-A140)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03264	CST3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cst3	NCBI	NCBI:1471
Mus musculus	Cst3	NCBI	NCBI:13010

Name
Email *

	Sorry, but the email address you supplied was invalid.