Htr4 - 5-hydroxytryptamine receptor 4 Gene

Rattus norvegicus

Gene ID: 25324 | Gene type: protein coding

About Htr4

Primary_assembly 18: 55,766,725-55,949,321 forward strand.mRatBN7.2:CM026991.1

This gene has 6 transcripts (splice variants), 201 orthologues, 35 paralogues and is associated with 10 phenotypes. Biased expression in Brain (RPKM 13.), Kidney (RPKM 3.6) and 4 other tissues.

Summary

Enables G protein-coupled serotonin receptor activity. Involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and gamma-aminobutyric acid signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 Products(1)

mRNA	Protein	Name
NM_012853.2	NP_036985.2	5-hydroxytryptamine receptor 4

Htr4 Protein Structure

7tmA_5-HT4

0
100
200
300
388 a.a.

Protein Preferred Names

Protein Names

5-hydroxytryptamine receptor 4

5 hydroxytryptamine ( serotonin) receptor 4	5-HT-4
5-HT4 receptor (two splicing variants L and S)	5-hydroxytryptamine (serotonin) receptor 4, G protein-coupled
serotonin receptor 4

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14153A	Tegaserod maleate		99.93%	Unkown
HY-14153	Tegaserod		99.89%	Unkown

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06474	HTR4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06475	Htr4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS06476	Htr4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14153S	Tegaserod-d11		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Htr4	NCBI	NCBI:3360

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