Adora2a - adenosine A2a receptor Gene

Rattus norvegicus

Also known as A2ar; ADENO; Adora2l1

Gene ID: 25369 | Gene type: protein coding

About Adora2a

Primary_assembly 20: 13,315,853-13,333,386 reverse strand.mRatBN7.2:CM026993.1

This gene has 1 transcript (splice variant), 263 orthologues, 3 paralogues and is associated with 36 phenotypes. Biased expression in Brain (RPKM 73.9), Lung (RPKM 63.2) and 8 other tissues.

Summary

Enables G protein-coupled Adenosine Receptor activity; alpha-actinin binding activity; and type 5 metabotropic glutamate receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and regulation of secretion. Located in several cellular components, including axolemma; postsynaptic density; and synaptic membrane. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Colocalizes with intermediate filament. Used to study lung disease. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2a Products(2)

mRNA	Protein	Name
NM_053294.5	NP_445746.3	adenosine receptor A2a A2AR
NM_001357942.1	NP_001344871.1	adenosine receptor A2a uORF5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled adenosine receptor activity	IDA IDA: Inferred from direct assay	12590138	RGD
enables alpha-actinin binding	IDA IDA: Inferred from direct assay	12837758	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16617164	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16481441	RGD
enables type 5 metabotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	12189203	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled adenosine receptor signaling pathway	IDA IDA: Inferred from direct assay	12590138	RGD
involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16478979	RGD
involved in astrocyte activation	IMP IMP: Inferred from mutant phenotype	12838511	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	12827647	RGD
involved in excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	16644907	RGD
involved in locomotory behavior	IMP IMP: Inferred from mutant phenotype	12827647	RGD
involved in membrane depolarization	IMP IMP: Inferred from mutant phenotype	16644907	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	16617164	RGD
involved in negative regulation of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	15211592	RGD
involved in negative regulation of neuron apoptotic process	IDA IDA: Inferred from direct assay	15211592	RGD
involved in negative regulation of protein kinase activity	IDA IDA: Inferred from direct assay	12590138	RGD
involved in negative regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	16815983	RGD
involved in neuron projection morphogenesis	IDA IDA: Inferred from direct assay	16617164	RGD
involved in neuron projection morphogenesis	IMP IMP: Inferred from mutant phenotype	12727227	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	12590138	RGD
involved in positive regulation of acetylcholine secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	12679375	RGD
involved in positive regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	16109808	RGD
involved in positive regulation of glutamate secretion	IDA IDA: Inferred from direct assay	16481441	RGD
involved in positive regulation of long-term synaptic potentiation	IMP IMP: Inferred from mutant phenotype	14596853	RGD
involved in positive regulation of protein secretion	IDA IDA: Inferred from direct assay	14742743	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	16481441	RGD
involved in positive regulation of urine volume	IMP IMP: Inferred from mutant phenotype	10070140	RGD
involved in prepulse inhibition	IMP IMP: Inferred from mutant phenotype	12827647	RGD
involved in presynaptic modulation of chemical synaptic transmission	EXP EXP: Inferred from Experiment	15659214	RGD
involved in presynaptic modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	15659214	RGD
involved in presynaptic modulation of chemical synaptic transmission	IEP IEP: Inferred from expression pattern	15659214	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	12189203	RGD
involved in regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15297571	RGD
involved in regulation of mitochondrial membrane potential	IDA IDA: Inferred from direct assay	15211592	RGD
involved in regulation of norepinephrine secretion	IMP IMP: Inferred from mutant phenotype	16539684	RGD
involved in response to alkaloid	IMP IMP: Inferred from mutant phenotype	16684876	RGD
involved in response to caffeine	IDA IDA: Inferred from direct assay	16481441	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	17853654	RGD
involved in synaptic transmission, cholinergic	IMP IMP: Inferred from mutant phenotype	15297571	RGD
involved in synaptic transmission, glutamatergic	IDA IDA: Inferred from direct assay	16644907	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	10070140	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in asymmetric synapse	IDA IDA: Inferred from direct assay	16481441	RGD
located in axolemma	IDA IDA: Inferred from direct assay	16481441	RGD
located in axon	IDA IDA: Inferred from direct assay	16952160	RGD
located in dendrite	IDA IDA: Inferred from direct assay	16952160	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	15659214	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15659214	RGD
located in intermediate filament	IDA IDA: Inferred from direct assay	16644907	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	16644907	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	23994616	RGD
is active in postsynaptic membrane	IDA IDA: Inferred from direct assay	16952160	RGD
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	16481441	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	16481441	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	16952160	RGD
located in presynaptic membrane	IDA IDA: Inferred from direct assay	16481441	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Adora2a Protein Structure

7tmA_Adenosine_R_A2A

0
100
200
300
410 a.a.

Protein Preferred Names

Protein Names

adenosine receptor A2a

Adenosine A2a-receptor

Adora2a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Adora2a	P30543	Cnr1	Rattus norvegicus	P20272	Anti Bait CoIP	17356572
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Pull Down	16617164
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Y2H	16617164
Cross	Adora2a	P30543	Tsnax	Mus musculus	Q9QZE7	Confocal	16617164

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170397	ADORA2A/PDE4D-IN-1		/	Unkown
HY-RS00394	ADORA2A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00395	Adora2a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS00396	Adora2a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Adora2a	NCBI	NCBI:135

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