Casp3 - caspase 3 Gene

Rattus norvegicus

Also known as Lice; Yama; CPP32-beta

Gene ID: 25402 | Gene type: protein coding

About Casp3

Primary_assembly 16: 45,662,910-45,684,648 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 334 orthologues, 12 paralogues and is associated with 107 phenotypes. Biased expression in Thymus (RPKM 222.5), Spleen (RPKM 187.9) and 9 other tissues.

Summary

Enables several functions, including death receptor binding activity; Phospholipase A2 activator activity; and protease binding activity. Involved in several processes, including luteolysis; nervous system development; and positive regulation of amyloid-beta formation. Located in cytosol; membrane raft; and neuronal cell body. Part of death-inducing signaling complex. Used to study artery disease (multiple); brain disease (multiple); and pre-malignant neoplasm. Biomarker of several diseases, including artery disease (multiple); brain disease (multiple); diabetes mellitus (multiple); heart disease (multiple); and pancreatitis (multiple). Human ortholog(s) of this gene implicated in Parkinson's disease; colon cancer; lung non-small cell carcinoma; and stomach Cancer. Orthologous to human CASP3 (Caspase 3). [provided by Alliance of Genome Resources, Apr 2022]

Casp3 Products(1)

mRNA	Protein	Name
NM_012922.2	NP_037054.1	caspase-3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type peptidase activity	IDA IDA: Inferred from direct assay	16336964	RGD
enables death receptor binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables phospholipase A2 activator activity	IMP IMP: Inferred from mutant phenotype	12492473	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	17518537	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	18485100	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	17518537	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axonal fasciculation	IMP IMP: Inferred from mutant phenotype	25898930	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16987298	RGD
involved in glial cell apoptotic process	IEP IEP: Inferred from expression pattern	18931364	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18459132	RGD
involved in intracellular signal transduction	IMP IMP: Inferred from mutant phenotype	12492473	RGD
involved in learning or memory	IMP IMP: Inferred from mutant phenotype	18239768	RGD
involved in leukocyte apoptotic process	IEP IEP: Inferred from expression pattern	26861981	RGD
involved in luteolysis	IEP IEP: Inferred from expression pattern	25332219	RGD
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	15248196	RGD
involved in positive regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	17553422	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	17869439	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18404518	RGD
involved in protein catabolic process	IDA IDA: Inferred from direct assay	15004018	RGD
involved in proteolysis	IDA IDA: Inferred from direct assay	17553422	RGD
involved in regulation of protein stability	IDA IDA: Inferred from direct assay	17553422	RGD
involved in response to X-ray	IEP IEP: Inferred from expression pattern	18239382	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	18423997	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	18598848	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	18288275	RGD
involved in response to glucose	IDA IDA: Inferred from direct assay	19356108	RGD
involved in response to hydrogen peroxide	IDA IDA: Inferred from direct assay	18479463	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	18466900	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18289516	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	18483861	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	18477628	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18255115	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	18274634	RGD
involved in striated muscle cell differentiation	IEP IEP: Inferred from expression pattern	28899909	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of death-inducing signaling complex	IDA IDA: Inferred from direct assay	17518537	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	25898930	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Casp3 Protein Structure

CASc

0
100
200
277 a.a.

Protein Preferred Names

Protein Names

caspase-3

CASP-3	CPP-32
CPP32beta	Caspase 3, apoptosis related cysteine protease (ICE-like cysteine protease)
IRP	SCA-1
SREBP cleavage activity 1	apopain
cysteine protease CPP32	cysteine protease p32-beta
protein Yama

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10656	Ac-DEVDD-TPP	Inducer	/	Unkown
HY-RS01952	CASP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01953	Casp3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01954	Casp3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Casp3	NCBI	NCBI:836

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