2. Gene
  3. Cd59 - CD59 molecule Gene

Cd59 - CD59 molecule Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cd59a; Cd59b; MACIF; MACIP; MAC-IP

Gene ID: 25407 | Gene type: protein coding

About Cd59

Summary

Enables complement binding activity. Involved in several processes, including negative regulation of activation of membrane attack complex; negative regulation of complement-dependent cytotoxicity; and positive regulation of T cell proliferation. Located in compact myelin; extracellular space; and sarcolemma. Used to study anterior uveitis; colorectal carcinoma; glomerulonephritis; nephrosis; and neuromyelitis optica. Biomarker of acute necrotizing pancreatitis; diabetic retinopathy; and myocardial infarction. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian Cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd59 Products(1)

mRNA Protein Name
NM_012925.2 NP_037057.1 CD59 glycoprotein precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables complement binding IDA
IDA: Inferred from direct assay
9038722 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of activation of membrane attack complex IDA
IDA: Inferred from direct assay
15843577 RGD
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
10807586 RGD
involved in negative regulation of complement-dependent cytotoxicity IMP
IMP: Inferred from mutant phenotype
28212662 RGD
involved in positive regulation of T cell proliferation IMP
IMP: Inferred from mutant phenotype
8621904 RGD
Cellular Component GO Annotation Evidence Reference Source
located in compact myelin IDA
IDA: Inferred from direct assay
12153479 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
9038722 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
7515561 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

CD59 glycoprotein

CD59 antigen

CD59 molecule, complement regulatory protein

CD59b moleucle, complement regulatory protein

Cb59b molecule

MAC-inhibitory protein

membrane attack complex inhibition factor

protectin

Recombinant Cd59 Proteins

Cat. No. Product Name Accession Purity
HY-P75390 CD59 Protein, Rat (HEK293, His) P27274 (L23-N100) ≥95%
HY-P75391 CD59 Protein, Rat (HEK293, Fc) P27274 (L23-N100) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02257 CD59 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cd59 NCBI NCBI:966
Macaca fascicularis Cd59 NCBI NCBI:101867071
Mus musculus Cd59 NCBI