2. Gene
  3. Ctsc - cathepsin C Gene

Ctsc - cathepsin C Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CATC; DPPI; DPP-I

Gene ID: 25423 | Gene type: protein coding

About Ctsc

Primary_assembly 1: 142,028,392-142,060,387 forward strand.mRatBN7.2:CM026974.1

This gene has 3 transcripts (splice variants), 233 orthologues, 27 paralogues and is associated with 15 phenotypes. Biased expression in Liver (RPKM 64.8), Kidney (RPKM 269.7) and 7 other tissues.

Summary

Enables several functions, including chaperone binding activity; chloride ion binding activity; and identical protein binding activity. Involved in several processes, including aging; positive regulation of proteolysis involved in cellular protein catabolic process; and proteolysis. Located in Golgi apparatus; endoplasmic reticulum; and lysosome. Biomarker of brain ischemia; hypertension; and obesity. Human ortholog(s) of this gene implicated in Papillon-Lefevre disease and aggressive periodontitis. Orthologous to human CTSC (Cathepsin C). [provided by Alliance of Genome Resources, Apr 2022]

Ctsc Products(2)

mRNA Protein Name
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor
NM_017097.2 NP_058793.1 dipeptidyl peptidase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables chloride ion binding IDA
IDA: Inferred from direct assay
11602245 RGD
enables identical protein binding IDA
IDA: Inferred from direct assay
11602245 RGD
enables phosphatase binding IPI
IPI: Inferred from physical interaction
18307834 RGD
enables protein-folding chaperone binding IPI
IPI: Inferred from physical interaction
18307834 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of proteolysis involved in protein catabolic process IDA
IDA: Inferred from direct assay
18307834 RGD
Cellular Component GO Annotation Evidence Reference Source
located in lysosome IDA
IDA: Inferred from direct assay
18307834 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctsc Protein Structure

CathepsinC_exc

CathepsinC_exc: pfam08773 (24 - 137)

Pox_I6

Pox_I6: cl28439 (167 - 203)

Peptidase_C1A_CathepsinC

Peptidase_C1A_CathepsinC: cd02621 (229 - 458)

  • 0
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  • 400
  • 462 a.a.
Protein Preferred Names Protein Names

dipeptidyl peptidase 1

cathepsin J

dipeptidyl peptidase I

dipeptidyl transferase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-112318A GSK-2793660 Inhibitor 99.91% Phase 1
HY-112318 GSK-2793660 free base Inhibitor / Phase 1
Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120709 GSK2793660 hydrochloride Inhibitor / Unkown
HY-168591 CTSC-IN-1 Inhibitor / Unkown
HY-RS03325 CTSC Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03326 Ctsc Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS03327 Ctsc Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ctsc NCBI NCBI:1075
Mus musculus Ctsc NCBI NCBI:13032