Fgf9 - fibroblast growth factor 9 Gene

Rattus norvegicus

Also known as Fgf4b

Gene ID: 25444 | Gene type: protein coding

About Fgf9

Summary

Enables Fibroblast Growth Factor receptor binding activity and growth factor activity. Involved in several processes, including negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching; positive regulation of vascular associated smooth muscle cell migration; and positive regulation of vascular associated smooth muscle cell proliferation. Acts upstream of or within positive regulation of MAPK cascade. Located in basement membrane and cytoplasm. Human ortholog(s) of this gene implicated in multiple synostoses syndrome. Orthologous to human FGF9 (Fibroblast Growth Factor 9). [provided by Alliance of Genome Resources, Apr 2022]

Fgf9 Products(1)

mRNA	Protein	Name
NM_012952.2	NP_037084.1	fibroblast growth factor 9

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables fibroblast growth factor receptor binding	IPI IPI: Inferred from physical interaction	15231666	RGD
enables growth factor activity	IDA IDA: Inferred from direct assay	15231666	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in fibroblast growth factor receptor signaling pathway	IDA IDA: Inferred from direct assay	15231666	RGD
involved in negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching	IMP IMP: Inferred from mutant phenotype	28259995	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	15231666	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	28259995	RGD
involved in positive regulation of vascular associated smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	28259995	RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	28259995	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basement membrane	IDA IDA: Inferred from direct assay	17494997	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fibroblast growth factor 9

FGF-9	GAF
HBGF-9	fibroblast growth factor 4b
glia-activating factor

Recombinant Fgf9 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7178	FGF-9 Protein, Rat	P36364 (L4-S208)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04907	FGF9 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fgf9	NCBI	NCBI:2254
Mus musculus	Fgf9	NCBI	NCBI:14180

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