Nog - noggin Gene

Rattus norvegicus

Gene ID: 25495 | Gene type: protein coding

About Nog

Summary

Predicted to enable cytokine binding activity and protein homodimerization activity. Involved in several processes, including hippocampus development; learning or memory; and regulation of gliogenesis. Located in axon and extracellular space. Part of protein-containing complex. Biomarker of acute kidney tubular necrosis and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism (multiple). Orthologous to human NOG (noggin). [provided by Alliance of Genome Resources, Apr 2022]

Nog Products(1)

mRNA	Protein	Name
NM_012990.1	NP_037122.1	noggin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15199066	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	15199066	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to BMP stimulus	IEP IEP: Inferred from expression pattern	21238590	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	25740156	RGD
involved in forebrain development	IEP IEP: Inferred from expression pattern	14643011	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	15171992	RGD
involved in memory	IMP IMP: Inferred from mutant phenotype	12740172	RGD
involved in mesenchymal cell differentiation	IMP IMP: Inferred from mutant phenotype	21238590	RGD
involved in negative regulation of astrocyte differentiation	IMP IMP: Inferred from mutant phenotype	14975730	RGD
involved in ossification	IEP IEP: Inferred from expression pattern	24611347	RGD
involved in positive regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	15265600	RGD
involved in positive regulation of oligodendrocyte progenitor proliferation	IMP IMP: Inferred from mutant phenotype	14975730	RGD
involved in visual learning	IMP IMP: Inferred from mutant phenotype	12740172	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	21447372	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	15199066	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15199066	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

noggin

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99836	Cudarolimab	Inhibitor	95.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-170451	KT-253		98.53%	Unkown
HY-163532	FLS-359	Modulator	/	Unkown
HY-170452	MDM2 ligand 4	Ligand	/	Unkown
HY-RS09410	NOG Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nog	NCBI	NCBI:9241
Canis familiaris	Nog	NCBI	NCBI:100683515
Macaca fascicularis	Nog	NCBI	NCBI:102145726
Mus musculus	Nog	NCBI	NCBI:18121
Leporidae	Nog	NCBI
Macaca mulatta	Nog	NCBI	NCBI:707338

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